Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
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DOI：
10.1016/j.cell.2006.06.049
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发表时间：
2006-08-25
期刊：
影响因子：
64.5
通讯作者：
Mangelsdorf, David J.
中科院分区：
文献类型：
--
作者：
Bookout, Angie L.;Jeong, Yangsik;Mangelsdorf, David J.
在多细胞生物中，调节生殖、发育和营养利用的能力与核受体（NRs）的进化相一致，核受体是利用亲脂配体介导其功能的转录因子。研究NRs的表达谱提供了一种简单而有力的方法，可以获得有关其作为单个蛋白质和超家族的生理功能的高度相关信息。我们调查了39个组织中所有49种小鼠NR mrna的表达，代表了不同的解剖系统。结果数据集揭示了几个NR分支，其表达模式表明它们协调转录程序的能力，这些转录程序是影响不同生理途径所必需的。值得注意的是，这种调节网络分为以下两种生理模式：(1)繁殖、发育和生长；(2)营养吸收、代谢和排泄。这些数据揭示了一个层次化的转录回路，它超越了个体组织，形成了一个在有机体尺度上控制生理的巨大网络。
In multicellular organisms, the ability to regulate reproduction, development, and nutrient utilization coincided with the evolution of nuclear receptors (NRs), transcription factors that utilize lipophilic ligands to mediate their function. Studying the expression profile of NRs offers a simple, powerful way to obtain highly relational information about their physiologic functions as individual proteins and as a superfamily. We surveyed the expression of all 49 mouse NR mRNAs in 39 tissues, representing diverse anatomical systems. The resulting data set uncovers several NR clades whose patterns of expression indicate their ability to coordinate the transcriptional programs necessary to affect distinct physiologic pathways. Remarkably, this regulatory network divides along the following two physiologic paradigms: (1) reproduction, development, and growth and (2) nutrient uptake, metabolism, and excretion. These data reveal a hierarchical transcriptional circuitry that extends beyond individual tissues to form a meganetwork governing physiology on an organismal scale.