EMG-force relation in the first dorsal interosseous muscle of patients with amyotrophic lateral sclerosis.
EMG-force relation in the first dorsal interosseous muscle of patients with amyotrophic lateral sclerosis.
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DOI：
10.3233/nre-141125
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发表时间：
2014-01-01
影响因子：
2
通讯作者：
Zhou P
中科院分区：
文献类型：
--
作者：
Jahanmiri-Nezhad F;Hu X;Suresh NL;Rymer WZ;Zhou P
表面肌电图（EMG）和肌肉力量之间的关系对于评估肌肉功能及其缺陷至关重要。然而，很少有研究探讨肌萎缩侧索硬化症（ALS）患者的肌电-力的关系。本研究的目的是探讨肌萎缩侧索硬化症患者的肌电-肌力关系及其与健康对照者的变化。记录表面肌电图和力信号，而10个ALS和10个年龄匹配的健康对照受试者产生等长自主收缩的第一背侧骨间（FDI）肌肉在整个范围内的激活。通过实验和预测EMG振幅之间的归一化均方根误差（RMSE）评价EMG-力关系的线性拟合。比较肌萎缩侧索硬化症患者和健康对照者的肌电-力关系。通过线性拟合，健康对照受试者的实验和预测EMG振幅之间的归一化RMSE为9.6 ± 3.6%，ALS受试者为12.3 ± 8.0%。ALS受试者的线性拟合斜率为2.9 ± 2.2 μVN−1，显著低于对照受试者（5.1 ± 1.8 μVN−1）（p < 0.05）。然而，在排除了4名最大力非常弱的ALS受试者后，其余ALS受试者的斜率为3.5 ± 2.2 μVN−1，与对照受试者没有显著差异（p > 0.05）。线性拟合可用于很好地描述ALS和健康对照受试者的FDI肌肉的EMG-力关系。各种过程可能在ALS中一起工作，这可能对EMG-力关系产生不利影响。
The relationship between surface electromyography (EMG) and muscle force is essential to assess muscle function and its deficits. However, few studies have explored the EMG-force relation in patients with amyotrophic lateral sclerosis (ALS). The purpose of this study was to examine the EMG-force relation in ALS subjects and its alteration in comparison with healthy control subjects. Surface EMG and force signals were recorded while 10 ALS and 10 age-matched healthy control subjects produced isometric voluntary contractions in the first dorsal interosseous (FDI) muscle over the full range of activation. A linear fit of the EMG-force relation was evaluated through the normalized root mean square error (RMSE) between the experimental and predicted EMG amplitudes. The EMG-force relation was compared between the ALS and the healthy control subjects. With a linear fit, the normalized RMSE between the experimental and predicted EMG amplitudes was 9.6 ± 3.6% for the healthy control subjects and 12.3 ± 8.0% for the ALS subjects. The slope of the linear fit was 2.9 ± 2.2 μVN−1 for the ALS subjects and was significantly shallower (p < 0.05) than the control subjects (5.1 ± 1.8 μVN−1). However, after excluding the four ALS subjects who had very weak maximum force, the slope for the remaining ALS subjects was 3.5 ± 2.2 μVN−1 and was not significantly different from the control subjects (p > 0.05). A linear fit can be used to well describe the EMG-force relation for the FDI muscle of both ALS and healthy control subjects. A variety of processes may work together in ALS that can adversely affect the EMG-force relation.