Respiratory status in dairy farmers in France; cross sectional and longitudinal analyses
Respiratory status in dairy farmers in France; cross sectional and longitudinal analyses
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DOI：
10.1136/oem.60.11.858
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发表时间：
2003-11-01
影响因子：
4.9
通讯作者：
Dalphin, JC
中科院分区：
文献类型：
--
作者：
Chaudemanche, H;Monnet, E;Dalphin, JC
目的：比较呼吸系统状况的奶农与非农业controls.Methods：纵向研究在杜布斯（法国）。从1994年组成的队列（T1），215（81.1%）奶农和110（73.8%）控制在1999年（T2）进行了重新评估。该方案包括医学和职业问卷调查、两次评估时的肺量测定、T1时的过敏试验和T2时的无创血氧饱和度（Spo（2））测量。在1999年的分析中，奶农的慢性支气管炎患病率高于对照组（p = 0.013），FEV 1/VC（p< 0.025）和Spo（2）（20.7%，p< 0.01）低于对照组。在多元线性回归模型中，农业，年龄和吸烟显着负相关与Spo 2。在整个人群中，FEV 1和FEV 1/ VC的平均年下降分别为-13.4ml和-0.30%。调整协变量后，农耕与FEV 1/ VC加速下降相关（p< 0.025）。除FEF 25 - 75外，未观察到过敏与呼吸功能变化之间的关系。结论：这项前瞻性研究表明，奶牛养殖与慢性支气管炎过度相关，伴有中度支气管阻塞和Spo 2轻度降低。
Aims: To compare respiratory status in dairy farmers with that of non-farming controls.Methods: Longitudinal study in the Doubs ( France). From a cohort constituted in 1994 (T1), 215 (81.1%) dairy farmers and 110 (73.8%) controls were reevaluated in 1999 (T2). The protocol comprised a medical and occupational questionnaire, spirometric tests at both evaluations, allergological tests at T1, and a noninvasive measure of blood oxygen saturation (Spo(2)) at T2.Results: In 1999 analyses, the prevalence of chronic bronchitis was higher ( p = 0.013), and FEV1/VC (p< 0.025) and Spo(2) (20.7%, p< 0.01) lower in dairy farmers than in controls. In a multiple linear regression model, farming, age, and smoking were significantly and inversely correlated with Spo2. In the whole population, the mean annual decline in FEV1 and FEV1/ VC was -13.4 ml and -0.30%, respectively. Farming was associated with an accelerated decline in FEV1/ VC ( p< 0.025) after adjustment for covariates. No relation between allergy and respiratory function changes was observed, except for FEF25-75.Conclusions: This prospective study shows that dairy farming is associated with an excess of chronic bronchitis, with a moderate degree of bronchial obstruction and a mild decrease in Spo2.