Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism.
Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism.
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DOI：
10.1186/1740-3391-10-4
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发表时间：
2012-05-15
影响因子：
--
通讯作者：
Shibata S
中科院分区：
文献类型：
--
作者：
Fuse Y;Hirao A;Kuroda H;Otsuka M;Tahara Y;Shibata S
最近对人类和啮齿动物的研究表明，食物摄入时间在昼夜节律调节和代谢健康中起着重要作用。在不活动期间或清醒期结束时食用高脂肪食物会导致啮齿动物体重增加和代谢综合征。然而，早餐份量和早餐/晚餐份量比例对代谢健康的明显影响尚未在小鼠身上得到充分研究。我们检查了在清醒期开始时吃大餐（早餐；一餐组）和在清醒期结束时吃相对少量餐（晚餐；两餐组）的小鼠的代谢综合征参数是否受到不同的影响。每天给各组小鼠提供等量的食物。与吃两顿饭的小鼠相比，吃一顿饭的小鼠体重增加增加，高胰岛素血症、高瘦素血症增加，并且脂肪组织和肝脏中与β-氧化相关的基因表达减少。与吃两顿饭的小鼠相比，吃一顿饭的小鼠时钟基因的昼夜节律表达模式受到干扰。总之，丰盛的早餐和较少的晚餐（每天两餐）而不是仅早餐（每天一餐）有助于控制高脂肪膳食计划小鼠的体重和脂肪积累。这项研究的结果表明，减肥和/或维持体重的饮食建议应包括饮食摄入时间和数量的信息。
Recent studies on humans and rodents have suggested that the timing of food intake plays an important role in circadian regulation and metabolic health. Consumption of high-fat foods during the inactive period or at the end of the awake period results in weight gain and metabolic syndrome in rodents. However, the distinct effects of breakfast size and the breakfast/dinner size ratio on metabolic health have not yet been fully examined in mice. We examined whether the parameters of metabolic syndrome were differentially affected in mice that consumed a large meal at the beginning of the awake period (breakfast; one meal group) and a relatively smaller meal at end of the awake period (dinner; two meals group). The mice of each group were provided equal food volume per day. Mice on one meal exhibited an increase in body weight gain, hyperinsulinemia, hyperleptinemia, and a decrease of gene expression associated with β-oxidation in adipose tissue and liver compared with those on two meals. The circadian expression pattern of the Clock gene in mice on one meal was disturbed compared with those on two meals. In conclusion, a bigger breakfast with a smaller dinner (two meals per day) but not breakfast only (one meal per day) helps control body weight and fat accumulation in mice on a high-fat meals schedule. The findings of this study suggest that dietary recommendations for weight reduction and/or maintenance should include information on the timing and quantity of dietary intake.