Three murine anxiety models: results from multiple inbred strain comparisons
Three murine anxiety models: results from multiple inbred strain comparisons
复制标题
DOI：
10.1111/j.1601-183x.2007.00385.x
复制
发表时间：
2008-06-01
影响因子：
2.5
通讯作者：
Crabbe, J. C.
中科院分区：
文献类型：
--
作者：
Milner, L. C.;Crabbe, J. C.
关于哪些模型反映了不同于一般活动的焦虑样行为，以及不同模型是否测量相同的潜在结构，围绕人类焦虑障碍啮齿动物模型的文献存在差异。本实验比较了15个近交系小鼠的反应（129 S1/SvlmJ、A/J、AKR/J、BALB/cByJ、C3 H/HeJ、C57 BL/6 J、C57 L/J、CBA/J、CE/J、DBA/2 J、FVB/NJ、NZB/B1 NJ、PL/J、SJL/J和SWR/J）在三种焦虑样行为任务中的反应（光/暗测试，高架零迷宫和开放视野）以检查反应是否在表型和/或遗传上与任务相关。发现所有变量检查的显着应变差异。主成分分析表明，与活动和焦虑样行为相关的变量加载到一个因素，而排尿和排便加载到另一个因素。我们的研究结果与以往的研究不同，表明一般活动和焦虑相关的行为是联系在一起的，负相关的，在这些测定中不能轻易分离。然而，这些发现可能不一定适用于其他无条件焦虑样行为测试。
The literature surrounding rodent models of human anxiety disorders is discrepant concerning which models reflect anxiety-like behavior distinct from general activity and whether different models are measuring the same underlying constructs. This experiment compared the responses of 15 inbred mouse strains (129S1/SvlmJ, A/J, AKR/J, BALB/cByJ, C3H/HeJ, C57BL/6J, C57L/J, CBA/J, CE/J, DBA/2J, FVB/NJ, NZB/B1NJ, PL/J, SJL/J and SWR/J) in three anxiety-like behavioral tasks (light/dark test, elevated zero-maze and open field) to examine whether responses were phenotypically and/or genetically correlated across tasks. Significant strain differences were found for all variables examined. Principal components analyses showed that variables associated with both activity and anxiety-like behaviors loaded onto one factor, while urination and defecation loaded onto another factor. Our findings differ from previous research by suggesting that general activity and anxiety-related behaviors are linked, negatively correlated and cannot easily be dissociated in these assays. However, these findings may not necessarily generalize to other unconditioned anxiety-like behavioral tests.