Limb-sparing in dogs using patient-specific, 3 dimensional-printed endoprosthesis for distal radial osteosarcoma: a pilot study.
Limb-sparing in dogs using patient-specific, 3 dimensional-printed endoprosthesis for distal radial osteosarcoma: a pilot study.
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使用患者特异性 3 维打印内置假体治疗远端桡骨骨肉瘤的狗的肢体保留：一项试点研究。
DOI：
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发表时间：
2020
影响因子：
2.1
通讯作者：
V. Brailovski
中科院分区：
文献类型：
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作者：
B. Séguin;C. Pinard;B. Lussier;Deanna Williams;L. Griffin;Brendan K. Podell;S. Mejia;A. Timercan;Y. Petit;V. Brailovski
保留肢体治疗桡骨远端骨肉瘤并发症发生率高。使用个性化三维(3D)打印植入物可能会改善结果。这项研究的目标是在临床环境中优化使用针对患者的3D打印内假体来保留狗的肢体，并报告结果。这是一项试验性研究，招募了五只客户拥有的狗。进行胸部四肢CT扫描，并在手术当天进行重复检查，以建立患者专用的假体和切割指南。在临床治疗中引入动脉内(IA)卡铂。行保肢手术。观察指标包括制作假体和切割导向器所需的时间、切割导向器和假体与宿主骨之间的配合、步态分析、肿瘤大小、肿瘤坏死率、并发症、无病间隔(DFI)和生存时间(ST)。四只狗接受了IA卡铂治疗。计划CT和手术之间的肿瘤过度生长在任何狗身上都没有发生。CT与手术的间隔时间为14~70天。切开导向器与假体与宿主骨之间的适合性良好至优良。所有的狗都出现了至少一种并发症。安乐死两只犬，STS分别为192天和531天。其余的狗都活了下来，随访时间为534到575天。IA化疗是一种有前景的策略，可以在等待人工假体和切割指南制作的同时，将肿瘤过度生长的风险降至最低。切割导向器的设计是假体与宿主骨最佳匹配的关键。这篇文章受版权保护。版权所有。
Limb-sparing for distal radial osteosarcoma has a high rate of complications. Using personalized 3 dimensional (3D)-printed implants might improve outcome. The goals of this study were to optimize use of patient-specific, 3D-printed endoprostheses for limb-sparing in dogs in the clinical environment and to report outcome. This was a pilot study where five client-owned dogs were enrolled. CT of the thoracic limbs was performed, which was used to create patient-specific endoprostheses and cutting guides, and repeated on the day of surgery. Intra-arterial (IA) carboplatin was introduced in the clinical management. Limb-sparing was performed. Outcome measures were time required to produce the endoprosthesis and cutting guide, fit between cutting guide and endoprosthesis with host bones, gait analysis, size of the tumor, percent tumor necrosis, complications, disease-free interval (DFI), and survival time (ST). Four dogs received IA carboplatin. Excessive tumor growth between planning CT and surgery did not occur in any dog. The interval between the CT and surgery ranged from 14 to 70 days. Fit between the cutting-guide and endoprosthesis with the host bones was good to excellent. At least one complication occurred in all dogs. Two dogs were euthanized with STs of 192 and 531 days. The other dogs were alive with a follow up of 534 to 575 days. IA chemotherapy is a promising strategy to minimize the risk of excessive tumor growth while waiting for the endoprosthesis and cutting-guide to be made. The design of the cutting-guide was critical for best fit of the endoprosthesis with host bones. This article is protected by copyright. All rights reserved.
DOI：
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发表时间：
1989
期刊：
Journal of the American Veterinary Medical Association
影响因子：
--
作者：
LaRue,SM;Withrow,SJ;Powers,BE;Wrigley,RH;Gillette,EL;Schwarz,PD;Straw,RC;Richter,SL
通讯作者：
Richter,SL