Controlled co-precipitation of biocompatible colorant-loaded nanoparticles by microfluidics for natural color drinks
Controlled co-precipitation of biocompatible colorant-loaded nanoparticles by microfluidics for natural color drinks
复制标题
通过微流体控制生物相容性着色剂负载纳米粒子的共沉淀用于天然色素饮料
DOI：
10.1039/c9lc00240e
复制
发表时间：
2019-06-21
期刊：
影响因子：
6.1
通讯作者：
Weitz, David A.
中科院分区：
文献类型：
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作者：
Kong, Linlin;Chen, Ran;Weitz, David A.
天然着色剂赋予食品鲜艳的颜色并增加额外的健康益处，比合成着色剂更受欢迎;然而，它们的应用受到其在水中的低溶解度和低稳定性的限制。在这里，我们开发了一种通用的微流体策略，将天然色素与控制的物理化学性质的虫胶纳米粒子。微流体通道中的快速混合确保混合时间短于聚集时间，从而提供对着色剂和聚合物的共沉淀的控制。通过引入分子相互作用，着色剂纳米聚集体有效地嵌入聚合物基质中，形成分层着色剂负载的纳米颗粒。分散在水中的着色剂负载的纳米颗粒在宽pH范围内是透明和稳定的，并且它们的聚合物基质还提供了有利的微环境，大大提高了着色剂的保质期。天然色素的溶解性、稳定性和生物利用度的改善表明虫胶纳米颗粒是理想的载体，并且生物相容性着色剂负载的纳米颗粒在水中的稳定、透明分散体非常适合于功能性食品如天然色素饮料的开发。
Natural colorants, which impart a vivid color to food and add additional health benefits, are favored over synthetic colorants; however, their applications are limited by their low solubility in water and low stability. Here, we develop a versatile microfluidic strategy to incorporate natural colorants in shellac nanoparticles with controlled physicochemical properties. The rapid mixing in the microfluidic channels ensures that the mixing time is shorter than the aggregation time, thus providing control over the co-precipitation of the colorant and the polymer. By introducing molecular interactions, colorant nanoaggregates are efficiently embedded in the polymer matrix, forming hierarchical colorant-loaded nanoparticles. The colorant-loaded nanoparticles dispersed in water are transparent and stable over a wide pH range and their polymer matrix also provides a favorable microenvironment that greatly improves the shelf life of the colorants. The improved solubility, stability and bioavailability of the natural colorants suggest that shellac nanoparticles are ideal carriers and the stable, transparent dispersions of biocompatible colorant-loaded nanoparticles in water are well-suited for the development of functional foods, such as natural color drinks.