Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus.
Identification of conserved and divergent domains within the envelope gene of the acquired immunodeficiency syndrome retrovirus.
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获得性免疫缺陷综合征逆转录病毒包膜基因内保守和不同结构域的鉴定。
DOI：
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发表时间：
1986
影响因子：
11.1
通讯作者：
Malcolma . Martin
中科院分区：
文献类型：
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作者：
Ronald L. Willey;Rosamond Rutledge;Susan Dias;Thomas FOLKSt;T. Theodore;C. Buckler;Malcolma . Martin
非洲和北美获得性免疫缺陷综合征（艾滋病）病毒分离株的包膜基因的核苷酸序列已经确定。当它们推导的氨基酸序列与淋巴结病和艾滋病相关的逆转录病毒分离株的包膜对齐时，很容易识别出保守和不同的区域。28-74个氨基酸的高变段，在每个位置表现出20-30%的氨基酸同一性，并以相互插入和缺失为特征，局限于gp 120外包膜蛋白。艾滋病病毒env基因多样性的起源和临床意义进行了讨论。
The nucleotide sequences of the envelope genes of an African and a North American acquired immunodeficiency syndrome (AIDS) viral isolate have been determined. When their deduced amino acid sequences were aligned with the envelopes of the lymphoadenopathy and AIDS-associated retrovirus isolates, conserved and divergent regions were readily identified. Hypervariable stretches of 28-74 amino acids, exhibiting 20-30% amino acid identity at each position and characterized by reciprocal insertions and deletions, were confined to the gp120 external envelope protein. The origin and clinical implications of the AIDS viral env gene diversity are discussed.