Experimental aerosol survival of SARS-CoV-2 in artificial saliva and tissue culture media at medium and high humidity
Experimental aerosol survival of SARS-CoV-2 in artificial saliva and tissue culture media at medium and high humidity
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DOI：
10.1080/22221751.2020.1777906
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发表时间：
2020-01-01
影响因子：
13.2
通讯作者：
Lever, Mark S.
中科院分区：
文献类型：
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作者：
Smither, Sophie J.;Eastaugh, Lin S.;Lever, Mark S.
SARS-CoV-2是COVID-19大流行的病原体，可能通过空气飞沫或接触飞沫沉积的表面传播。在这项研究中，SARS-CoV-2在黑暗中，在两个不同的相对湿度值和人工唾液，一个临床相关的矩阵，生存的能力进行了研究。SARS-CoV-2在黑暗中，在我们测试的四种实验条件下，在动态小颗粒气溶胶中是稳定的，90分钟后仍然可以检测到活病毒。测定了衰变率和半衰期，不同条件下的衰变率范围为0.4 - 2.27%/min，半衰期范围为30 - 177 min。这些信息可用于咨询和建模以及潜在的缓解战略。
SARS-CoV-2, the causative agent of the COVID-19 pandemic, may be transmitted via airborne droplets or contact with surfaces onto which droplets have deposited. In this study, the ability of SARS-CoV-2 to survive in the dark, at two different relative humidity values and within artificial saliva, a clinically relevant matrix, was investigated. SARS-CoV-2 was found to be stable, in the dark, in a dynamic small particle aerosol under the four experimental conditions we tested and viable virus could still be detected after 90 minutes. The decay rate and half-life was determined and decay rates ranged from 0.4 to 2.27 % per minute and the half lives ranged from 30 to 177 minutes for the different conditions. This information can be used for advice and modelling and potential mitigation strategies.