Locally implantable nanofibre meshes by sustained release of temozolomide for combined thermo-chemotherapy to treat glioblastoma
Locally implantable nanofibre meshes by sustained release of temozolomide for combined thermo-chemotherapy to treat glioblastoma
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DOI：
10.1039/d3nj00534h
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发表时间：
2023-02-21
影响因子：
3.3
通讯作者：
Ebara，Mitsuhiro
中科院分区：
文献类型：
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作者：
Oe，Emiho;Fujisawa，Nanami;Ebara，Mitsuhiro
胶质母细胞瘤(GBM)是一种高度恶性的脑肿瘤，起源于成人的星形胶质细胞或支持性脑组织。虽然有几种治疗选择，但复发率仍然很高，5年预期存活率不到10%。这项研究通过控制纤维形态，研究了能够在4周内长期释放替莫唑胺(TMZ)的纳米纤维网状物。通过电纺可生物降解聚合物聚(ε-己内酯)(PCL)制备了纳米纤维网。所得网状物具有良好的柔韧性，可作为局部颅内给药平台。纳米纤维网还携带磁性纳米颗粒(MNPs)，使与交变磁场(AMF)相对应的热疗/化疗联合治疗成为可能。在高温温度范围内(∼42.6C)成功地调节了纳米纤维网的生热行为。负载TMZ/MNP的纳米纤维网可通过热疗和化疗的协同作用，使GBM癌细胞(T98G)的细胞活力降低76%。这些结果表明，纳米纤维网作为一种植入性的颅内药物输送系统，作为手术和放射治疗的辅助手段，对GBM患者具有潜在的应用价值。
Glioblastoma (GBM) is a highly malignant type of brain tumour that arises from astrocytes or supportive brain tissue in adults. Although there are several therapeutic options, recurrence rates remain high, with a 5 year survival rate expectancy of less than 10%. This study investigates nanofibre meshes that enable the long-term release of temozolomide (TMZ) over a 4 week period by controlling the fibre morphologies. The nanofibre meshes were fabricated via the electrospinning of a biodegradable polymer, poly(ε-caprolactone) (PCL). The obtained meshes were flexible and implantable as a local intracranial drug delivery platform. The nanofibre meshes also carry magnetic nanoparticles (MNPs) that enable the combined therapy of hyperthermia/chemotherapy corresponding to an alternating magnetic field (AMF). The heat generation behaviour of the nanofibre meshes was successfully adjusted in a hyperthermic temperature range (∼42.6 °C). The TMZ/MNP-loaded nanofibre meshes showed a 76% reduction in the cell viability of GBM cancer (T98G) cells through the synergistic effect of hyperthermia and chemotherapy. These results indicated the potential applications of nanofibre meshes as an implantable intracranial drug delivery system as an adjunct to surgery and radiation for GBM patients.