Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate
Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate
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DOI：
10.1038/tpj.2010.51
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发表时间：
2011-10-01
影响因子：
2.8
通讯作者：
Mann, K.
中科院分区：
文献类型：
--
作者：
Kiefer, F.;Witt, S. H.;Mann, K.
在酗酒中，饮酒复发和治疗反应都被认为是基因调节的。本研究旨在确定最近全基因组关联 (GWA) 和酒精依赖后续研究的前 15 个单核苷酸多态性 (SNP) 是否与 374 名酒精依赖受试者的复发行为和药物治疗反应相关，这些受试者接受了阿坎酸、纳曲酮或安慰剂的随机、双盲、安慰剂对照试验。单核苷酸多态性 rs13273672 是 GATA 结合蛋白 4 (GATA4) 基因中的一个内含子 SNP，与 90 天治疗期内的复发相关（P
In alcoholism, both relapse to alcohol drinking and treatment response are suggested to be genetically modulated. This study set out to determine whether the top 15 single nucleotide polymorphisms (SNPs) of a recent genome-wide association (GWA) and follow-up study of alcohol dependence are associated with relapse behavior and pharmacological treatment response in 374 alcohol-dependent subjects who underwent a randomized, double-blind, placebo-controlled trial with acamprosate, naltrexone or placebo. The single nucleotide polymorphism, rs13273672, an intronic SNP in the gene for GATA-binding protein 4 (GATA4), was associated with relapse within the 90-day medical treatment period (P