CRANIOFACIAL ABNORMALITIES INDUCED BY ECTOPIC EXPRESSION OF THE HOMEOBOX GENE HOX-1.1 IN TRANSGENIC MICE
CRANIOFACIAL ABNORMALITIES INDUCED BY ECTOPIC EXPRESSION OF THE HOMEOBOX GENE HOX-1.1 IN TRANSGENIC MICE
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DOI：
10.1016/0092-8674(89)90848-9
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发表时间：
1989-07-28
期刊：
影响因子：
64.5
通讯作者：
KESSEL, M
中科院分区：
文献类型：
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作者：
BALLING, R;MUTTER, G;KESSEL, M
Hox-1.1是小鼠在胚胎发生过程中以时间和细胞特异性方式表达的含有同源盒的基因。我们已经从鸡的β中产生了异位表达Hox-1.1的转基因小鼠。肌动蛋白启动子。在这些小鼠中，Hox-1.1的表达变化为几乎无处不在的模式。Hox-1.1的异位表达导致转基因动物在出生后不久死亡，并与多种颅面异常有关，如腭裂、出生时睁眼和耳廓不融合。这种表型类似于妊娠期间全身服用维甲酸后所见的效果。这表明维甲酸胚胎病和由潜在发育控制基因异位表达引起的特定发育缺陷具有共同的致病机制。
Hox-1.1 is a murine homeobox-containing gene expressed in a time- and cell-specific manner during embryogenesis. We have generated transgenic mice that ectopically express Hox-1.1 from the chicken .beta.-actin promoter. In these mice Hox-1.1 expression was changed to an almost ubiquitous pattern. Ectopic expression of Hox-1.1 leads to death of the transgenic animals shortly after birth and is associated with multiple craniofacial anomalies, such as cleft palate, open eyes at birth, and nonfused pinnae. This phenotype is similar to the effects seen after systemic administration of retinoic acid during gestation. This suggests that retinoic acid embryopathy and the specific developmental defects caused by ectopic expression of a potential developmental control gene share a common pathogenic mechanism.