2 TYPES OF COMPLEMENTARY DNAS OF RAT-BRAIN PROTEIN-KINASE-C - HETEROGENEITY DETERMINED BY ALTERNATIVE SPLICING
2 TYPES OF COMPLEMENTARY DNAS OF RAT-BRAIN PROTEIN-KINASE-C - HETEROGENEITY DETERMINED BY ALTERNATIVE SPLICING
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DOI：
10.1016/0014-5793(86)81010-9
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发表时间：
1986-10-06
期刊：
影响因子：
3.5
通讯作者：
NISHIZUKA, Y
中科院分区：
文献类型：
--
作者：
ONO, Y;KUROKAWA, T;NISHIZUKA, Y
分离了两种大鼠脑蛋白激酶C的互补DNA克隆。这些克隆编码671和673个氨基酸序列，它们彼此仅在约100个氨基酸的羧基末端区域不同。50个氨基酸残基。这种差异似乎是由选择性剪接引起的。这些cDNA克隆的序列以及从纯化的大鼠脑酶的一些肽的阐明表明在该组织中存在另外的蛋白激酶C。这是有吸引力的想象，蛋白激酶C的异质性可能反映了不同的信号转导途径进入细胞。
Two types of complementary DNA clones for rat brain protein kinase C were isolated. These clones encode 671 and 673 amino acid sequences, which differ from each other only in the carboxyl‐terminal regions of approx. 50 amino acid residues. This difference seems to result from alternative splicing. Elucidation of the sequences of these cDNA clones as well as some peptides from the purified rat brain enzyme suggests the existence of an additional species of protein kinase C in this tissue. It is attractive to imagine that the heterogeneity of protein kinase C may reflect diverse pathways of signal transduction into the cell.