Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease.
Consequences of brain-derived neurotrophic factor withdrawal in CNS neurons and implications in disease.
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DOI：
10.1016/j.nbd.2016.03.009
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发表时间：
2017-01
影响因子：
6.1
通讯作者：
Chao MV
中科院分区：
文献类型：
--
作者：
Mariga A;Mitre M;Chao MV
生长因子的退出已经在不同物种中进行了研究，并已被证明对细胞存活具有显着的后果。在神经系统中，神经生长因子（NGF）从交感神经元和感觉神经元中的撤回导致大量神经元细胞死亡，这表明周围神经系统（PNS）中神经元的存活需要NGF。与PNS相反，撤除富含脑源性神经营养因子（BDNF）的中枢神经系统（CNS）对细胞存活的影响很小，但对突触可塑性是必不可少的。鉴于神经精神疾病的大多数早期事件都以突触丢失为标志，因此BDNF的缺乏可能是导致神经元变性的级联事件的重要组成部分。在这里，我们回顾了有关BDNF退出对CNS神经元的影响的报道，并讨论了疾病中的损失的相关性。
Growth factor withdrawal has been studied across different species and has been shown to have dramatic consequences on cell survival. In the nervous system, withdrawal of nerve growth factor (NGF) from sympathetic and sensory neurons results in substantial neuronal cell death, signifying a requirement for NGF for the survival of neurons in the peripheral nervous system (PNS). In contrast to the PNS, withdrawal of central nervous system (CNS) enriched brain-derived neurotrophic factor (BDNF) has little effect on cell survival but is indispensible for synaptic plasticity. Given that most early events in neuropsychiatric disorders are marked by a loss of synapses, lack of BDNF may thus be an important part of a cascade of events that leads to neuronal degeneration. Here we review reports on the effects of BDNF withdrawal on CNS neurons and discuss the relevance of the loss in disease.