Circulating Concentrations of GDF11 are Positively Associated with TSH Levels in Humans
Circulating Concentrations of GDF11 are Positively Associated with TSH Levels in Humans
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DOI：
10.3390/jcm8060878
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发表时间：
2019-06-01
影响因子：
3.9
通讯作者：
Gomez-Ambrosi, Javier
中科院分区：
文献类型：
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作者：
Anon-Hidalgo, Juan;Catalan, Victoria;Gomez-Ambrosi, Javier
生长分化因子11（GDF 11）是转化生长因子（TGF）-β超家族的成员，其随着年龄的增长而下降，并且已被提出作为在小鼠骨骼肌中具有再生作用的抗衰老因子。然而，最近在人类和小鼠中的数据相互矛盾，对其真正的功能作用产生了怀疑。本研究的目的是分析GFD 11在能量稳态中的潜在参与，特别是与甲状腺激素的关系。采用酶联免疫吸附试验（ELISA）检测287例受试者的血清GDF 11浓度。GDF 11与促甲状腺激素（TSH）浓度呈显著正相关（r = 0.40，p < 0.001）。静息能量消耗（REE）和每单位去脂质量的REE（REE/FFM）与GDF 11水平均无显著相关性（p > 0.05）。在多元线性回归分析中，最能预测logGDF 11的模型包括logTSH、瘦素、体重指数（BMI）、年龄和C反应蛋白（logCRP）。该模型解释了logGDF 11浓度总变异性的37%（p < 0.001），只有logTSH是logGDF 11的显著预测因子。在通过TSH水平分离受试者后，与正常TSH组或高TSH组相比，低TSH组中的那些表现出显著降低的（p < 0.05）GDF 11浓度。GDF 11水平与logCRP显著相关（r = 0.19，p = 0.025），与高血压和心脏病无关。总之，我们的结果表明，GDF 11的循环浓度与TSH浓度密切相关，并且在低TSH水平的受试者中降低。然而，GDF 11与能量消耗的调节无关。我们的数据还表明，GDF 11可能参与炎症的调节，而与心脏功能无关。需要进一步的研究来阐明GDF 11在代谢中的作用及其在甲状腺病理生理学中的潜在参与。
Growth differentiation factor 11 (GDF11) is a member of the transforming growth factor (TGF)-beta superfamily which declines with age and has been proposed as an anti-aging factor with regenerative effects in skeletal muscle in mice. However, recent data in humans and mice are conflicting, casting doubts about its true functional actions. The aim of the present study was to analyze the potential involvement of GFD11 in energy homeostasis in particular in relation with thyroid hormones. Serum concentrations of GDF11 were measured by enzyme-linked immunosorbent assay (ELISA) in 287 subjects. A highly significant positive correlation was found between GDF11 and thyroid-stimulating hormone (TSH) concentrations (r = 0.40, p < 0.001). Neither resting energy expenditure (REE) nor REE per unit of fat-free mass (REE/FFM) were significantly correlated (p > 0.05 for both) with GDF11 levels. In a multiple linear regression analysis, the model that best predicted logGDF11 included logTSH, leptin, body mass index (BMI), age, and C-reactive protein (logCRP). This model explained 37% of the total variability of logGDF11 concentrations (p < 0.001), with only logTSH being a significant predictor of logGDF11. After segregating subjects by TSH levels, those within the low TSH group exhibited significantly decreased (p < 0.05) GDF11 concentrations as compared to the normal TSH group or the high TSH group. A significant correlation of GDF11 levels with logCRP (r = 0.19, p = 0.025) was found. GDF11 levels were not related to the presence of hypertension or cardiopathy. In conclusion, our results show that circulating concentrations of GDF11 are closely associated with TSH concentrations and reduced in subjects with low TSH levels. However, GDF11 is not related to the regulation of energy expenditure. Our data also suggest that GDF11 may be involved in the regulation of inflammation, without relation to cardiac function. Further research is needed to elucidate the role of GDF11 in metabolism and its potential involvement in thyroid pathophysiology.