Flavonoids from dark chocolate and (-)-epicatechin ameliorate high-fat diet-induced decreases in mobility and muscle damage in aging mice.
Flavonoids from dark chocolate and (-)-epicatechin ameliorate high-fat diet-induced decreases in mobility and muscle damage in aging mice.
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黑巧克力中的黄酮类化合物和 (-)-表儿茶素可改善高脂肪饮食引起的衰老小鼠活动能力下降和肌肉损伤。
DOI：
10.1016/j.fbio.2020.100710
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发表时间：
2020
期刊：
影响因子：
5.2
通讯作者：
Najera,Nayelli
中科院分区：
文献类型：
--
作者：
Munguia,Levy;Ramirez-Sanchez,Israel;Meaney,Eduardo;Villarreal,Francisco;Ceballos,Guillermo;Najera,Nayelli
与年龄相关的肌肉衰退，如果与肥胖相关，会导致跌倒、丧失独立能力、残疾和过早死亡风险增加等不良后果。本研究的目的是评估黄酮类化合物在改善年龄/高脂肪饮食引起的与骨骼肌衰退相关的身体活动/能力下降方面的潜在有益作用。在摄入高脂肪饮食（60%脂肪）引起的中年小鼠身体活动下降模型中，对富含黄烷醇或纯(−)-表儿茶素的可可饮料给予5周的影响进行了评估。结果表明，与对照组相比，两种产品，富含黄烷醇和纯(−)-表儿茶素的可可饮料，通过悬挂线，倒屏，举重测试和动力学测试评估了物理性能。饮料和(−)-表儿茶素增加了卵泡生长抑制素/肌肉生长抑制素比率，增加了肌细胞增强因子2A （MEF2A）的表达，表明对生长分化的分子调节剂有影响。此外，饮料和(−)-表儿茶素降低了骨骼肌泛素-蛋白酶体降解途径的o型叉头转录因子（FOXO1A）和肌肉环指1 （MURF1）标记物的表达。
Age-related muscle decline, when associated with obesity, leads to adverse outcomes with increased risks for falling, loss of independence, disability and risk of premature mortality. The aim of this study was to assess the potential beneficial effects of flavonoids in improving the age-/high-fat-diet-induced decrease in physical activity/capacity related to the onset of skeletal muscle decline. The effects of the administration of a cocoa beverage enriched with flavanols or pure (−)-epicatechin for 5 wk in a model of physical activity decline induced by the ingestion of a high-fat diet (60% fat) in middle-age mice were evaluated. The results showed that both products, the cocoa beverage enriched with flavanols and pure (−)-epicatechin, improved physical performance evaluated with the hang-wire, inverted-screen, and weight-lifting tests and dynamometry compared with the performance of the controls. The beverage and (−)-epicatechin increased the follistatin/myostatin ratio and increased the expression of myocyte enhancer factor 2A (MEF2A), suggesting an effect on molecular modulators of growth differentiation. Furthermore, the beverage and (−)-epicatechin decreased the expression of O-type fork-head transcription factor (FOXO1A) and muscle ring finger 1 (MURF1) markers of the skeletal muscle ubiquitin-proteasome degradation pathway.