Characterization of port wine stain skin erythema and melanin content using cross-polarized diffuse reflectance imaging
Characterization of port wine stain skin erythema and melanin content using cross-polarized diffuse reflectance imaging
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DOI：
10.1002/lsm.10242
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发表时间：
2004-01-01
影响因子：
2.4
通讯作者：
Nelson, JS
中科院分区：
文献类型：
--
作者：
Jung, BJ;Choi, C;Nelson, JS
背景和目标：目的探讨激光治疗鲜红斑痣（PWS）的临床疗效。先前的研究试图基于点测量设备客观地评估PWS颜色。迄今为止，这些方法通常受到许多因素的限制，例如小的测试区域和需要接触。为了解决这些问题，一个交叉偏振漫反射成像系统和彩色图像分析方法已经开发出来，以评估定量红斑和黑色素含量PWS skin.Study设计/材料和方法：一个交叉偏振漫反射系统已被构建，以获得高分辨率的数字图像，同时尽量减少文物，如眩光，阴影，和不均匀的照明效果，可以损害图像保真度。此外，还开发了图像分析算法，以根据CIEL*a*B* 颜色空间参数来分析正常和PWS皮肤。使用该算法，图像的颜色空间强度，L*，和饱和度，a*，指数已被计算提取定量指标的黑色素和红斑，respectively.Results：相比，交叉偏振漫反射图像，a* 指数图像增强了高，低红斑区域的对比度。并且似乎与L* 索引图像具有准相关性。在所提出的PWS患者的例子中，相对a* 指数差（Deltaa*）图像显示较少的红斑在PWS皮肤激光治疗后相比，pretreatment values.Conclusions：我们的交叉偏振成像系统和彩色图像分析方法是一种简单的，非接触式的技术，可以间接提供定量测量红斑。和黑色素含量。激光外科（C）2004 Wiley-Liss，Inc.
Background and Objectives: Objective methods to assess quantitatively port wine stain (PWS) blanching in response to laser therapy are needed to improve laser therapeutic outcome. Previous studies have attempted to assess objectively PWS color based on point measurement devices. To date, these approaches have typically been limited by a number of factors such as small test area and need for contact. To address these issues, a cross-polarized diffuse reflectance imaging system and color image analysis method has been developed to evaluate quantitatively erythema and melanin content in PWS skin.Study Design/Materials and Methods: A cross-polarized diffuse reflectance system has been constructed to acquire high resolution digital images while minimizing artifacts such as glare, shadowing, and nonuniform illumination effects that can compromise image fidelity. Furthermore, an image analysis algorithm has also been developed to analyze normal and PWS skin in terms of CIEL*a*b* color space parameters. Using the algorithm, images of color space intensity, L*, and saturation, a*, indices have been calculated to extract quantitative metrics of melanin and erythema, respectively.Results: Compared to the cross-polarized diffuse reflectance image, the a* index image enhanced the contrast in regions of high and low erythema. and seems to have quasi correlation with the L* index image. In the presented PWS patient example, the relative a* index difference (Deltaa*) image showed less erythema in PWS skin after laser treatment when compared to pre-treatment values.Conclusions: Our cross-polarized imaging system and color image analysis method is a simple, noncontact technique that can indirectly provide quantitative measurement of erythema. and melanin content in PWS skin. Lasers Surg. (C) 2004 Wiley-Liss, Inc.