Chemistry and Pharmacological Importance of1,3,4-Oxadiazole Derivatives
Chemistry and Pharmacological Importance of1,3,4-Oxadiazole Derivatives
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发表时间：
2015-04
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通讯作者：
R. Sharma;N. Kumar;R. Yaday
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作者：
R. Sharma;N. Kumar;R. Yaday
恶二唑是一种重要的五元环含一个氧原子和两个氮原子的杂环化合物。1，3，4-恶二唑是一种具有新颖分子的多功能杂环核，吸引着药物化学家寻找新的治疗分子。本文综述了1，3，4-恶二唑类化合物的理化性质、合成方法及药理活性。1，3，4-恶二唑是一种重要的药效团，在药物化学和广泛的重要生物活性中起着重要作用，如抗炎、镇痛、致溃疡、抗微生物、抗真菌、抗结核、抗惊厥、抗癌/抗肿瘤、抗病毒和抗高血压活性等。
Oxadiazole is an important heterocyclic compound containing one oxygen and two nitrogen atoms in the five membered ring. 1,3,4-oxadiazole is a versatile heterocyclic nucleus having novel molecule which attract the medicinal chemist to search a new therapeutic molecule. The present review summarizes physicochemical properties, various synthetic procedures and various pharmacological activities of 1,3,4-oxadiazole moiety. 1,3,4-oxadiazole moiety is an important pharmacophore which plays a major role in the pharmaceutical chemistry and broad range of important biological activities such as anti-inflammatory, analgesic, ulcerogenic, antimicrobial, antifungal antitubercular, anticonvulsant, anticancer/antitumor, antiviral, and antihypertensive activities etc. as reported in the literature.