Facilitatory action of muscarine on the slow afterdepolarization of rat dorsolateral septal nucleus neurons in vitro.
Facilitatory action of muscarine on the slow afterdepolarization of rat dorsolateral septal nucleus neurons in vitro.
复制标题
毒蕈碱对体外大鼠背外侧间隔核神经元缓慢后去极化的促进作用。
DOI：
10.1016/0304-3940(90)90209-r
复制
发表时间：
1990
影响因子：
2.5
通讯作者：
Gallagher,JP
中科院分区：
文献类型：
--
作者：
Hasuo,H;Gallagher,JP
Intracellular recordings were made from an isolated rat brain slice preparation containing the dorsolateral septal nucleus (DLSN). Calcium-dependent slow afterdepolarizations (slow-ADPs) were observed in a population of neurons, which exhibited bursts of action potentials. Bath application of muscarine (10–20 μM) augmented the slow-ADP and triggered burst firing on top of the slow-ADP. This effect of muscarine was blocked by atropine (1 μM). Muscarine augmented the slowly decaying inward current (slow-ADC) recorded by voltage clamping the afterpotential of cathodally-evoked spikes. Our data suggest that some of the burst-like activity induced by muscarine in a select population of rat DLSN neurons is mediated partly by augmentation of the current which underlies the slow-ADP.
