ANTINUTRITIVE EFFECTS OF WHEAT-GERM-AGGLUTININ AND OTHER N-ACETYLGLUCOSAMINE-SPECIFIC LECTINS
ANTINUTRITIVE EFFECTS OF WHEAT-GERM-AGGLUTININ AND OTHER N-ACETYLGLUCOSAMINE-SPECIFIC LECTINS
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DOI：
10.1079/bjn19930124
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发表时间：
1993-07-01
影响因子：
3.6
通讯作者：
BARDOCZ, S
中科院分区：
文献类型：
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作者：
PUSZTAI, A;EWEN, SWB;BARDOCZ, S
掺入N-乙酰葡糖胺特异性凝集素小麦胚芽（小麦; WGA），刺苹果（曼陀罗）或荨麻（荨麻）根茎在饮食中的水平为7克/公斤的表观消化率和利用率的饮食蛋白质和大鼠的生长，WGA是最具破坏性的。由于它们被小肠上皮细胞结合和内吞，所有三种凝集素都是肠道的生长因子，并在不同程度上干扰其代谢和功能。A工作组特别有效;它通过增加蛋白质、RNA和DNA的含量而诱导小肠的广泛的多胺依赖性增生和肥大生长。此外，内吞的WGA的相当大的部分被运输穿过肠壁进入体循环，在那里它沉积在血管和淋巴管的壁中。WGA还诱导胰腺肥大生长并引起胸腺萎缩。尽管人们提倡将WGA基因转移到农作物中以提高其抗虫性，但由于饮食中这种凝集素的存在可能会在有效对抗大多数害虫所需的浓度下伤害高等动物，因此它在植物中的使用作为天然杀虫剂对人类来说并非没有健康风险。
Incorporation of N-acetylglucosamine-specific agglutinins from wheat germ (Triticum aestivum; WGA), thorn apple (Datura stramonium) or nettle (Urtica dioica) rhizomes in the diet at the level of 7 g/kg reduced the apparent digestibility and utilization of dietary proteins and the growth of rats, with WGA being the most damaging. As a result of their binding and endocytosis by the epithelial cells of the small intestine, all three lectins were growth factors for the gut and interfered with its metabolism and function to varying degrees. WGA was particularly effective; it induced extensive polyamine-dependent hyperplastic and hypertrophic growth of the small bowel by increasing its content of proteins, RNA and DNA. Furthermore, an appreciable portion of the endocytosed WGA was transported across the gut wall into the systemic circulation, where it was deposited in the walls of the blood and lymphatic vessels. WGA also induced the hypertrophic growth of the pancreas and caused thymus atrophy. Although the transfer of the gene of WGA into crop plants has been advocated to increase their insect resistance, as the presence of this lectin in the diet may harm higher animals at the concentrations required to be effective against most pests, its use in plants as natural insecticide is not without health risks for man.