Invasive micropapillary carcinoma of the breast - Association of pathologic features with lymph node metastasis
Invasive micropapillary carcinoma of the breast - Association of pathologic features with lymph node metastasis
复制标题
DOI：
10.1309/axyy4ajtmnw6frmw
复制
发表时间：
2006-11-01
影响因子：
3.5
通讯作者：
Fu, Li
中科院分区：
文献类型：
--
作者：
Guo, Xiaojing;Chen, Ling;Fu, Li
乳腺浸润性微乳头状癌（IMPC）的特点是腋窝淋巴结转移的发生率高。为探讨病理特征与淋巴结转移的关系，对51例具有IMPC成分的乳腺癌进行研究。对血管内皮生长因子（VEGF）-C和VEGF受体（VEGFR）-3进行免疫组织化学分析，并测量淋巴管密度。主要发现包括组织学分级较高、淋巴细胞间质浸润显着、VEGF-C表达和淋巴管密度较高的IMPC中阳性淋巴结数量显着增加和/或淋巴结转移率增加。肿瘤中IMPC成分的百分比与淋巴结转移的发生率无关。结果提示IMPC的组织学分级、淋巴管密度、淋巴细胞浸润是影响淋巴结转移的关键因素。需要进一步的研究来阐明这种独特的乳腺癌变体的趋淋巴性的机制。
Invasive micropapillary carcinoma (IMPC) of the breast is characterized by a high incidence of axillary lymph node metastasis. To investigate the relationship between pathologic features and lymph node metastasis, 51 cases of breast carcinoma with IMPC components were studied. Immunohistochemical analysis for vascular endothelial growth factor (VEGF)-C and VEGF receptor (VEGFR)-3 was performed, and lymphatic vessel density was measured. The main findings included a significantly increased number of positive lymph nodes and/or an increased rate of lymph node metastasis in IMPC with a higher histologic grade, prominent stromal infiltration of lymphocytes, and higher VEGF-C expression and lymphatic vessel density. The percentage of IMPC component in the tumor was not associated with the incidence of lymph node metastasis. The results suggest that the histologic grade, lymphatic vessel density, and lymphocyte infiltration of IMPC are the key factors that influence lymph node metastasis. Further studies are required to elucidate the mechanisms underlying the lymphotropism of this distinct variant of breast carcinoma.