Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
Effects of selective NMDA and non-NMDA blockade in the nucleus accumbens on the plus-maze test
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DOI：
10.1016/s0031-9384(02)00704-7
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发表时间：
2002-06-01
影响因子：
2.9
通讯作者：
Gargiulo, PA
中科院分区：
文献类型：
--
作者：
Martínez, G;Ropero, C;Gargiulo, PA
本实验观察了阻断N-甲基-D-天冬氨酸(NMDA)受体和非NMDA-谷氨酸能受体对双侧伏核(ACC)雄性大鼠正迷宫成绩的影响。大鼠分为7组，分别在实验前15分钟注射生理盐水，(+/-)2-氨基-7-膦庚酸(AP-7，0.2，0.5或1杯)或2，3二氧-6-硝基-1，2，3，4，四氢苯并-(F)喹恶啉-7-磺胺二钠(NBQX，0.2，0.5或1杯)。记录张开手臂所花费的时间、每次进入的时间、到达终点的时间、打开手臂、关闭手臂和总手臂进入的时间、开放手臂、关闭手臂和总手臂的关系、直立、面部、头部和身体的清洁，以及大便排出的数量。在AP-7(0.5和1杯；P<；.01)和NBQX(1杯；P<；.05)治疗下，在张开手臂上花费的时间增加，而每次进入的时间仅在AP-7(1杯；P<；.05)组增加。中等剂量的AP-7(0.5mug；P<；.01)和NBQX(0.5mug；P<；.05)增加了开放的手臂进入；AP-7的中等剂量(0.5mug/l，P<；0.05)增加了最终到达。饲养、梳理和闭合手臂进入的频率不受治疗的影响。我们的结论是，在中等剂量时，Ac内的NMDA和非NMDA-谷氨酸能受体阻滞剂导致对皮质影响的行为解除抑制，但在较高剂量时，阻滞剂具有抗焦虑的作用。(C)2002 Elsevier Science Inc.保留所有权利。
Effect of blocking N-methyl-D-aspartic acid (NMDA) and non-NMDA-glutamatergic receptors on performance in the plus-maze was studied in male rats bilaterally cannulated into the nucleus accumbens (Acc). Rats were divided into seven groups that received either 1 mul injections of saline, (+/-)2-amino-7-phosphonoheptanoic acid (AP-7, 0.2, 0.5, or 1 mug) or 2,3 dioxo-6-nitro-1,2,3,4,tetrahydrobenzo-(f)quinoxaline-7-sulphonamide disodium (NBQX, 0.2, 0.5, or 1 mug) 15 min before testing. Time spent in open arm, time per entry, end arrivals, open, closed, and total arm entries, relationship between open-, closed-, and total arm entries, rearing, face-, head-, and body grooming, and number of fecal boli were recorded. Time spent in the open arm increased under AP-7 (0.5 and 1 mug; P < .01) and NBQX (1 mug; P < .05) treatment, whereas time per entry was increased only with AP-7 (1 mug; P < .05). Open arm entries were increased by the intermediate doses of AP-7 (0.5 mug; P < .01) and NBQX (0.5 mug; P < .05); end arrivals were increased by the intermediate dose of AP-7 (0.5 mug/1 mul, P < .05). The frequency of rearing, grooming, and closed arm entries was not affected by the treatment. We conclude that NMDA and non-NMDA-glutamatergic blockade in the Acc lead to a behavioral disinhibition of cortical influences with the median doses, but that at higher doses the blockers have an anxiolytic-like effect. (C) 2002 Elsevier Science Inc. All rights reserved.