Bone Marrow Metastasis of Rhabdomyosarcoma Mimicking Acute Leukemia: A Case Report and Review of the Literature
Bone Marrow Metastasis of Rhabdomyosarcoma Mimicking Acute Leukemia: A Case Report and Review of the Literature
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DOI：
10.2169/internalmedicine.54.2473
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发表时间：
2015-01-01
影响因子：
1.2
通讯作者：
Kobayashi, Hikaru
中科院分区：
文献类型：
--
作者：
Aida, Yuka;Ueki, Toshimitsu;Kobayashi, Hikaru
据报道横纹肌肉瘤的骨髓转移难以与急性白血病区分。我们在此报告一例横纹肌肉瘤伴急性淋巴细胞白血病的骨髓转移。一名29岁女性因血小板减少症、外周血胚状细胞和凝血障碍入院。骨髓穿刺显示94.8%的细胞样浸润(CD45(-)，髓过氧化物酶（-）和CD56(+))， CT扫描显示鼻腔内有浸润性肿块。根据鼻腔活检，患者被诊断为横纹肌肉瘤，表现为骨髓转移。她接受了化疗，随后又接受了放射治疗，到最后一次随访时，她已经存活了26个月。
Bone marrow metastasis of rhabdomyosarcoma has been reported to be difficult to distinguish from acute leukemia. We herein describe a case of rhabdomyosarcoma with bone marrow metastasis mimicking acute lymphoblastic leukemia. A 29-year-old woman was admitted with thrombocytopenia, blast-like cells in the peripheral blood and a coagulation disorder. Bone marrow aspirates showed 94.8% blast-like cell infiltration (CD45(-), myeloperoxidase(-), and CD56(+)), and CT scan revealed the presence of an infiltrating mass in the nasal cavity. Based on a biopsy of the nasal cavity, the patient was diagnosed with rhabdomyosarcoma exhibiting bone marrow metastasis. She received chemotherapy, followed by radiation therapy, and has since remained alive for 26 months, as of the last follow-up.