α2-Adrenergic receptors appear in rat salivary glands after reserpine treatment
α2-Adrenergic receptors appear in rat salivary glands after reserpine treatment
复制标题
利血平治疗后大鼠唾液腺中出现α2-肾上腺素能受体
DOI：
10.1038/285229a0
复制
发表时间：
1980
期刊：
影响因子：
64.8
通讯作者：
J. R. Martinez
中科院分区：
文献类型：
--
作者：
D. Bylund;J. R. Martinez
各种化学、生理、药理和病理刺激对中枢和外周肾上腺素能受体的调节一直是深入研究的主题1，2。例如，药物治疗可以在各种组织中现有受体结合位点的密度中产生相对较小的变化。用放射性配体受体结合技术研究了大鼠唾液腺组织中的α-肾上腺素能受体3。我们最近在大鼠下颌下腺中鉴定并表征了α1-肾上腺素能受体4，但令人惊讶的是，未检测到α2-肾上腺素能受体结合。我们现在报道利血平单次处理导致α2-肾上腺素能结合位点在12小时内出现。持续给药可进一步增加α2-肾上腺素能受体的数量，因此7天后α1-和α2-肾上腺素能受体的水平相似。这是药物治疗导致出现以前无法检测到的受体类型的第一个例子。
The regulation of central and peripheral adrenergic receptors by various chemical, physiological, pharmacological and pathological stimuli has been the subject of intense study1,2. For example, drug treatments can produce relatively small changes in the density of existing receptor binding sites in a variety of tissues. The α-adrenergic receptors in rat salivary gland tissue have been studied using radioligand receptor binding techniques3. We have recently identified and characterised α1-adrenergic receptors in the rat submandibular gland4, but surprisingly, α2-adrenergic receptor binding was not detectable. We now report that a single treatment of reserpine results in the appearance of α2-adrenergic binding sites within 12 h. Continued treatment with the drug produces further increases in the number of α2-adrenergic receptors, such that after 7 days the levels of α1- and α2-adrenergic receptors are similar. This is the first example of a drug treatment resulting in the appearance of a receptor type which was not previously detectable.