Corticomotor excitability induced by anodal transcranial direct current stimulation with and without non-exhaustive movement
Corticomotor excitability induced by anodal transcranial direct current stimulation with and without non-exhaustive movement
复制标题
DOI：
10.1016/j.brainres.2013.07.026
复制
发表时间：
2013-09-05
期刊：
影响因子：
2.9
通讯作者：
Yamamoto, Noriaki
中科院分区：
文献类型：
--
作者：
Miyaguchi, Shota;Onishi, Hideaki;Yamamoto, Noriaki
我们研究了在非力竭性主动或被动运动期间应用于运动皮层的阳极经颅直流电刺激（tDCS）是否会增强tDCS后的皮质运动兴奋性，或者如果在没有tDCS的情况下观察到PED，则在非力竭性主动或被动运动后是否会减少运动后抑郁（PED）。9名健康受试者参加了本研究。将电流为2 mA的阳极tDCS施加到左侧头皮的主要运动区。所有受试者均接受了以下五种干预：放松期间tDCS输送10分钟（tDCS条件）和重复自愿和被动手指外展-内收运动，每种运动均在无tDCS和有tDCS的情况下进行10分钟（主动条件、tDCS+主动条件、被动条件、tDCS+被动条件）。主动运动以10%最大自主收缩进行。在干预前（干预前）和干预后2 min和10 min（分别为干预后2 min和干预后10 min）记录右侧第一骨间背侧肌的运动诱发电位（MEP）。在tDCS条件下，MEP振幅在干预后2和-10 min与干预前相比显著增加。在主动、被动和tDCS+主动条件下，干预后2 min MEP振幅较干预前显著降低。在tDCS+被动条件下，MEP振幅保持不变。这些结果表明，阳极tDCS不会减少主动运动后的PED，但被动运动后，阳极tDCS的影响是高度依赖于受试者在刺激期间的状态。(C)2013爱思唯尔有限公司版权所有。
We investigated whether anodal transcranial direct current stimulation (tDCS) applied to the motor cortex during non-exhaustive active or passive movements enhances corticomotor excitability after tDCS or whether it reduces post-exercise depression (PED) after non-exhaustive active or passive movements if PED was observed without tDCS. Nine healthy subjects participated in this study. Anodal tDCS with a current of 2 mA was applied to the left scalp over the primary motor area. All subjects underwent the following five interventions: tDCS delivered for 10 min during relaxation (tDCS condition) and repetitive voluntary and passive finger abduction-adduction movements, each performed without and with tDCS for 10 min (active condition, tDCS+active condition, passive condition, tDCS+passive condition). The active movements were performed at 10% maximum voluntary contraction. Motor evoked potentials (MEPs) were recorded from the right first dorsal interosseus muscle before the intervention (pre-intervention) and 2 and 10 min after the intervention (post-2 min and post-10 min, respectively). Under the tDCS condition, the MEP amplitudes at post-2 and -10 min were significantly increased compared with those before the intervention. Under the active, passive, and tDCS+active conditions, the MEP amplitudes at post-2 min were significantly decreased compared with those before the interventions. Under the tDCS+passive condition, the MEP amplitude remained unchanged. These results demonstrated that anodal tDCS did not reduce PED after active movements but after passive movements and that the anodal tDCS effects were highly dependent on the state of the subject during stimulation. (C) 2013 Elsevier B.V. All rights reserved.