The effect of pH on the self-assembly of a collagen derived peptide amphiphile
The effect of pH on the self-assembly of a collagen derived peptide amphiphile
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DOI：
10.1039/c3sm51029h
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发表时间：
2013-01-01
期刊：
影响因子：
3.4
通讯作者：
Mezzenga, Raffaele
中科院分区：
文献类型：
--
作者：
Dehsorkhi, Ashkan;Castelletto, Valeria;Mezzenga, Raffaele
观察到带有阳离子五肽头基的自组装多肽两亲物(PA)在pH的驱动下纳米结构的转变。在pH为3时，PA形成扁平的带状结构，而在pH为4时，PA组装成扭曲的右手结构。在pH为7时，这些扭曲的结构再次转变为扁平的带状结构。与之完全相反，在pH为2时观察到球形胶束。这些随pH的变化可能与该PA在护肤品中的生物和药物应用有关。
Transitions in nanostructure driven by pH are observed for a self-assembling peptide amphiphile (PA) with a cationic pentapeptide headgroup. At pH 3, the PA forms flat tape-like structures, while at pH 4 the PA assembles into twisted right handed structures. These twisted structures transform again to flat tape-like structures at pH 7. In complete contrast, spherical micelles are observed at pH 2. These changes in response to pH may be relevant to biological and pharmaceutical applications of this PA in skincare.