Regulation of mouse NK cell development and function by cytokines.
Regulation of mouse NK cell development and function by cytokines.
复制标题
DOI：
10.3389/fimmu.2013.00450
复制
发表时间：
2013-12-12
影响因子：
7.3
通讯作者：
Walzer T
中科院分区：
文献类型：
--
作者：
Marçais A;Viel S;Grau M;Henry T;Marvel J;Walzer T
自然杀伤（NK）细胞是先天性淋巴细胞，在抵抗细胞内病原体和肿瘤的早期防御中具有重要作用。像其他免疫细胞一样，它们生物学的几乎每个方面都受到细胞因子的调节。白细胞介素（IL）-15对于它们的发育、稳态和活化至关重要。此外，许多其它活化或抑制性细胞因子如IL-2、IL-4、IL-7、IL-10、IL-12、IL-18、IL-21、转化生长因子-β（TGFβ）和I型干扰素在免疫应答的不同阶段调节它们的活化和它们的效应子功能。在这篇综述中，我们总结了目前的理解，这些不同的细胞因子对NK细胞的发展，稳态和功能在稳态或感染不同病原体。我们试图描绘这些细胞因子的细胞来源，它们触发的细胞内途径和它们调节的转录因子。我们描述了已知的协同作用或不同的细胞因子之间的拮抗作用，并强调在这一领域的调查突出的问题。最后，我们讨论了如何更好地了解细胞因子对NK细胞的作用，可以帮助改善策略，在不同的临床情况下操纵NK细胞。
Natural Killer (NK) cells are innate lymphocytes with an important role in the early defense against intracellular pathogens and against tumors. Like other immune cells, almost every aspects of their biology are regulated by cytokines. Interleukin (IL)-15 is pivotal for their development, homeostasis, and activation. Moreover, numerous other activating or inhibitory cytokines such as IL-2, IL-4, IL-7, IL-10, IL-12, IL-18, IL-21, Transforming growth factor-β (TGFβ) and type I interferons regulate their activation and their effector functions at different stages of the immune response. In this review we summarize the current understanding on the effect of these different cytokines on NK cell development, homeostasis, and functions during steady-state or upon infection by different pathogens. We try to delineate the cellular sources of these cytokines, the intracellular pathways they trigger and the transcription factors they regulate. We describe the known synergies or antagonisms between different cytokines and highlight outstanding questions in this field of investigation. Finally, we discuss how a better knowledge of cytokine action on NK cells could help improve strategies to manipulate NK cells in different clinical situations.