A perspective of coronary disease seen through the arteries of living man.
A perspective of coronary disease seen through the arteries of living man.
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通过活人的动脉观察冠心病的视角。
DOI：
10.1161/01.cir.75.3.505
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发表时间：
1987
期刊：
影响因子：
37.8
通讯作者：
Hickey,A
中科院分区：
文献类型：
--
作者：
Forrester,JS;Litvack,F;Grundfest,W;Hickey,A
“一场旷日持久的争论，”伏尔泰（他自己也是一个无可救药的争论者）喜欢说，“意味着双方都错了。”心脏病学上最长的争论是关于急性冠状动脉疾病的发病机制。今天，解决方案似乎近在咫尺：血栓再次成为急性梗死的原因，而溶栓是治疗方法。我们不希望像伏尔泰那样说，这种共识是错误的，但它是不完整的，因为它没有回答一系列关键的病理生理学问题：冠状动脉血栓形成之前有什么事件？血栓形成开始后，除梗塞外还有其他结局吗？什么时候可以阻止急性（或慢性）冠状动脉综合征的发展？我们的观点提出了一个系统的描述-一个范式-急性和慢性冠状动脉疾病的病理生理学在人，具体处理这三个问题。在过去的一年里，我们利用纤维光学血管镜对活人的冠状动脉进行了一次比喻性的航行。通过这一探索，我们已经看到冠状动脉内皮表面在急性和慢性冠状动脉综合征。我们意想不到的发现是，每一个常见的临床表现似乎都有一个特定的，可识别的内皮病理。我们将首先描述
" A LONG DISPUTE," Voltaire (himself an incorrigi-ble disputant) was fond of saying," means both parties are wrong." Cardiology's longest debate concerns the pathogenesis of acute coronary disease. Today the resolution seems at hand: thrombus is once again the cause of acute infarction and thrombolysis is its cure. We do not wish to say, as Voltaire might, that this consensus is wrong, but it is incomplete because it leaves unanswered a crucial set of pathophysiologic questioins: What events precede coronary thrombosis? After formation of thrombus begins, are there fates other than infarction? At what points can the evolution of any of the acute (or chronic) coronary syndromes be arrested? Our Perspective proposes a systematic de-scription-a paradigm-of the pathophysiology of acute and chronic coronary artery disease in man that deals specifically with these three questions. In the past year we have taken a metaphoric voyage through the coronary arteries of living man, using fi-beroptic angioscopes. Through this exploration, we have seen the coronary endothelial surface in both acute and chronic coronary syndromes. Our unanticipated discovery has been that each of the common clinical presentations seems to have a specific, identifiable endothelial pathology. We will first describe
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DOI：
10.1001/jama.1973.03220390021005
发表时间：
1973
期刊：
JAMA
影响因子：
--
作者：
M. Friedman;J. Manwaring;R. Rosenman;G. Donlon;P. Ortega;S. M. Grube
通讯作者：
S. M. Grube
DOI：
10.1016/0002-9149(74)90703-6
发表时间：
1974-12
期刊：
The American journal of cardiology
影响因子：
--
作者：
A. Chandler;I. Chapman;L. Erhardt;W. Roberts;C. Schwartz;D. Sinapius;D. Spain;S. Sherry;P. Ness;T. Simon
通讯作者：
A. Chandler;I. Chapman;L. Erhardt;W. Roberts;C. Schwartz;D. Sinapius;D. Spain;S. Sherry;P. Ness;T. Simon
影响因子：
158.5
作者：
CAIRNS, JA;GENT, M;TANSER, PH
通讯作者：
TANSER, PH
影响因子：
7.5
作者：
J. Lawrence;J. Shepherd;I. Bone;A. Rogen;W. Fulton
通讯作者：
W. Fulton
影响因子：
2.8
作者：
MULCAHY, R;DALY, L;TOBIN, G
通讯作者：
TOBIN, G