The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients
The effect of moderate exercise on postprandial glucose homeostasis in NIDDM patients
复制标题
DOI：
10.1007/s001250050699
复制
发表时间：
1997-04-01
期刊：
影响因子：
8.2
通讯作者：
Galbo, H
中科院分区：
文献类型：
--
作者：
Larsen, JJS;Dela, F;Galbo, H
本文首次研究了运动对非胰岛素依赖型糖尿病（NIDDM）患者餐后血糖的影响。对9名饮食治疗的NIDDM患者进行8小时的膳食诱导葡萄糖反应随访，受试者吃标准化早餐，4小时后吃标准化午餐。他们在休息状态（对照日（CD））和另一天在早餐后45分钟进行45分钟的自行车运动(53 +/- 2% (V)比dot (max)（O2)（平均+/- SEM））（运动日（ED））。在第3天（饮食日（DD）），根据运动期间额外的能量消耗减少早餐餐量。反应以早餐（B-AUC）或午餐（L-AUC）后4小时的血浆浓度曲线下面积（AUG）计算。葡萄糖的B-AUC在ED上相同（215 +/- 63 mmol/l）。240 min)和DD （219 +/- 60 mmol/l）。与CD组（453 +/- 78 mmol/l）相比（p < 0.05）明显降低。240分钟)。葡萄糖在CD、ED和DD的L-AUC无显著差异。与CD相比，ED和DD患者胰岛素和c肽的B-AUCs也显著降低（胰岛素：31337 +/- 8682、26092 +/- 6457和47649 +/- 15046 mmol/l）。分别为240分钟。c肽：99 +/- 19,104 +/- 26和195 +/- 31 pmol/ml。葡萄糖的出现率（Ra）不受运动影响，而消失率（Rd）显著增加。午餐后，Ra和Rd均无差异。综上所述，中等强度的餐后运动降低了NIDDM患者早餐后的血糖和血浆胰岛素水平，但这种效果在接下来的午餐期间和之后并不持续。减少早餐热量摄入对餐后血糖和胰岛素分泌的影响与运动引起的热量消耗增加相同。
The influence of exercise on glycaemia in the post-prandial state was studied for the first lime in non-insulin-dependent diabetic (NIDDM) patients. Meal-induced glucose responses were followed for 8 h in 9 diet-treated patients with NIDDM, Subjects consumed a standardized breakfast and 4 h later a standardized lunch. They were studied in the resting state (control day (CD)) and on another day 45 min of bicycle exercise (53 +/- 2% (V) over dot (max)(O2) (mean +/- SEM)) was performed 45 min after breakfast (exercise day (ED)). On day 3 (diet day (DD)), the breakfast meal was reduced corresponding to the extra energy expenditure during the exercise period on ED. Responses were calculated as areas under the plasma concentration curve (AUG) during 4 h after either breakfast (B-AUC) or lunch (L-AUC). B-AUC for glucose was identical on ED (215 +/- 63 mmol/l . 240 min) and DD (219 +/- 60 mmol/l . 230 min) and on these days lower (p < 0.05) than on CD (453 +/- 78 mmol/l . 240 min). L-AUC for glucose on CD, ED and DD did not differ significantly. B-AUCs for both insulin and C-peptide were also significantly lower on ED and DD as compared to CD (Insulin: 31337 +/- 8682, 26092 +/- 6457 and 47649 +/- 15046 mmol/l . 240 min, respectively. C-peptide: 99 +/- 19, 104 +/- 26 and 195 +/- 31 pmol/ml . 240 min, respectively), Rate of appearance (Ra) for glucose was unaffected by exercise whereas rate of disappearance (Rd) increased significantly. No differences in Ra or Rd were observed after lunch. In conclusion, postprandial exercise of moderate intensity decreases glycaemia and plasma insulin levels after breakfast in NIDDM patients, but this effect does not persist during and after the following lunch meal. Reduction of breakfast caloric intake has the same effect on postprandial glycaemia and insulin secretion as an equivalent exercise-induced increase in caloric expenditure.