Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses
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DOI：
10.1016/s0092-8674(00)81444-0
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发表时间：
1998-05-29
期刊：
影响因子：
64.5
通讯作者：
Ihle, JN
中科院分区：
文献类型：
--
作者：
Teglund, S;McKay, C;Ihle, JN
多种细胞因子介导Janus蛋白酪氨酸激酶（Jaks）的活化。然后，Jaks磷酸化细胞底物，包括转录因子的信号转导子和转录激活子（Stat）家族的成员。在Stats中，两种高度相关的蛋白质Stat5a和Stat5b被多种细胞因子激活。为了评估Stat5蛋白的作用，衍生出具有单独或一起缺失的基因的突变小鼠。小鼠的表型显示出两种Stat5蛋白在与生长激素和催乳素相关的生理反应谱中的重要且通常是多余的作用。相反，对激活Stat5蛋白的各种细胞因子的反应，包括促红细胞生成素，在很大程度上不受影响。
A variety of cytokines mediate the activation of Janus protein tyrosine kinases (Jaks). The Jaks then phosphorylate cellular substrates, including members of the signal transducers and activators of transcription (Stat) family of transcription factors. Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines. To assess the role of the Stat5 proteins, mutant mice were derived that have the genes deleted individually or together. The phenotypes of the mice demonstrate an essential, and often redundant, role for the two Stat5 proteins in a spectrum of physiological responses associated with growth hormone and prolactin. Conversely, the responses to a variety of cytokines that activate the Stat5 proteins, including erythropoietin, are largely unaffected.