A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer
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DOI：
10.1016/j.stem.2010.04.001
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发表时间：
2010-06-04
期刊：
影响因子：
23.9
通讯作者：
Wong, Benjamin C. Y.
中科院分区：
文献类型：
--
作者：
Pang, Roberta;Law, Wai Lun;Wong, Benjamin C. Y.
最近的证据表明，癌症细胞的一个亚群，癌症干细胞（CSCs），负责结直肠癌的肿瘤生长。然而，CSCs在结直肠癌转移中的作用尚不清楚。在这里，我们发现了一个CD26（+）细胞亚群，在肝转移的结直肠癌患者的原发性和转移性肿瘤中都均匀存在。此外，在发病时无远处转移的患者中，其原发肿瘤中CD26（+）细胞的存在预示着随访时的远处转移。将分离的CD26（+）细胞，而不是CD26（-）细胞注射到小鼠盲肠壁上，导致远处转移的发生。CD26（+）细胞也与增强的侵袭性和化疗耐药有关。我们的发现揭示了CSCs在癌症转移进展中的关键作用。此外，基于原发肿瘤中CSC亚群的分析预测转移的能力可能作为辅助治疗的选择标准具有重要的临床意义。
Recent evidence suggests that a subpopulation of cancer cells, cancer stem cells (CSCs), is responsible for tumor growth in colorectal cancer. However, the role of CSCs in colorectal cancer metastasis is unclear. Here, we identified a subpopulation of CD26(+) cells uniformly present in both the primary and metastatic tumors in colorectal cancer patients with liver metastasis. Furthermore, in patients without distant metastasis at the time of presentation, the presence of CD26(+) cells in their primary tumors predicted distant metastasis on follow-up. Isolated CD26(+) cells, but not CD26(-) cells, led to development of distant metastasis when injected into the mouse cecal wall. CD26(+) cells were also associated with enhanced invasiveness and chemoresistance. Our findings have uncovered a critical role of CSCs in metastatic progression of cancer. Furthermore, the ability to predict metastasis based on analysis of CSC subsets in the primary tumor may have important clinical implication as a selection criterion for adjuvant therapy.