Work-Related Exposure to Extremely Low-Frequency Magnetic Fields and Dementia: Results from the Population-Based Study of Dementia in Swedish Twins
Work-Related Exposure to Extremely Low-Frequency Magnetic Fields and Dementia: Results from the Population-Based Study of Dementia in Swedish Twins
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DOI：
10.1093/gerona/glq112
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发表时间：
2010-11-01
影响因子：
5.1
通讯作者：
Gatz, Margaret
中科院分区：
文献类型：
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作者：
Andel, Ross;Crowe, Michael;Gatz, Margaret
我们研究了极低频磁场（EMF）与痴呆和阿尔茨海默病风险之间的关系，使用了来自瑞典双胞胎痴呆研究（HARMONY）的所有9508名个体，并提供了有效的职业和诊断数据。痴呆症的诊断是基于电话筛查和面对面的临床检查。根据已建立的电磁场暴露矩阵对主要终生职业进行编码。协变量包括年龄、性别、教育程度、血管危险因素和工作复杂性。基于先前的研究，数据还分别分析了75岁与75岁以后发病的病例、男性与女性、体力与非体力主要职业的病例。我们使用了整个样本的广义估计方程（为了调整完整双胞胎的包含）和仅完整双胞胎的条件逻辑回归。电磁场暴露水平与痴呆或阿尔茨海默病没有显著关联。然而，在分层分析中，在75岁发病的病例中（优势比：1.94,95%置信区间：1.07-3.65；优势比：2.01,95%置信区间：1.10-3.65）和从事体力劳动的参与者中（优势比：1.81,95%置信区间：1.06-3.09；优势比：1.75,95%置信区间：1.00-3.05），中等和高水平的EMF暴露与低水平的痴呆风险增加相关。结果42对不一致的双胞胎痴呆发生率无统计学意义。职业性电磁场暴露似乎主要与早发性痴呆和前体力劳动者相关。
We examined the association between extremely low-frequency magnetic fields (EMF) and the risk of dementia and Alzheimer's disease using all 9,508 individuals from the Study of Dementia in Swedish Twins (HARMONY) with valid occupational and diagnostic data.Dementia diagnoses were based on telephone screening followed by in-person clinical workup. Main lifetime occupation was coded according to an established EMF exposure matrix. Covariates were age, gender, education, vascular risk factors, and complexity of work. Based on previous research, data were also analyzed separately for cases with disease onset by age 75 years versus later, men versus women, and those with manual versus nonmanual main occupation. We used generalized estimating equations with the entire sample (to adjust for the inclusion of complete twin pairs) and conditional logistic regression with complete twin pairs only.Level of EMF exposure was not significantly associated with dementia or Alzheimer's disease. However, in stratified analyses, medium and high levels of EMF exposure were associated with increased dementia risk compared with low level in cases with onset by age 75 years (odds ratio: 1.94, 95% confidence interval: 1.07-3.65 for medium, odds ratio: 2.01, 95% confidence interval: 1.10-3.65 for high) and in participants with manual occupations (odds ratio: 1.81, 95% confidence interval: 1.06-3.09 for medium, odds ratio: 1.75, 95% confidence interval: 1.00-3.05 for high). Results with 42 twin pairs discordant for dementia did not reach statistical significance.Occupational EMF exposure appears relevant primarily to dementia with an earlier onset and among former manual workers.