Evaluation of a model of the cochlear neural membrane. I. Physiological measurement of membrane characteristics in response to intrameatal electrical stimulation
Evaluation of a model of the cochlear neural membrane. I. Physiological measurement of membrane characteristics in response to intrameatal electrical stimulation
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DOI：
10.1016/s0378-5955(00)00109-x
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发表时间：
2000-08-01
期刊：
影响因子：
2.8
通讯作者：
Miller, RL
中科院分区：
文献类型：
--
作者：
Cartee, LA;van den Honert, C;Miller, RL
为了理解听觉神经对类似于人工耳蜗中使用的电刺激的反应，有必要了解神经折射和求和反应动力学。有证据表明，细胞体可能改变听神经反应动力学，并且可能是外周过程启动的兴奋传导失败的部位。然而，有理由相信，在一些健康的I型神经元和病理的III型神经元中，兴奋部位是细胞的中心过程。为了描述在受控的中央过程位点激活时的神经反应，用孔内电极刺激猫听觉神经元，并测量了求和和折射反应动力学。该方法用于：(1)表征中枢过程激励下的神经反应行为；(2)比较已知中心部位的内耳激励和未知部位的鼓室激励；(3)提供不受细胞胞体产生的膜动力学可能改变的膜表征。使用鼓室刺激测量的膜动力学与鼓室刺激记录的膜动力学不同，表明鼓室刺激和鼓室刺激的机制不同。(C) 2000 Elsevier Science B.V.版权所有
To understand the auditory neural response to electrical stimuli similar to those used in a cochlear implant, it will be necessary to understand the neural refraction and summation response kinetics. Evidence exists indicating that the cell soma may alter the auditory neural response kinetics and could be the site of conduction failure for excitation initiated on the peripheral process. There is, however, reason to believe that the excitation site in some healthy, type I neurons and in pathological, type III neurons is the central process of the cell. To characterize the neural response to activation at a controlled central process site, cat auditory neurons were stimulated with an intrameatal electrode, and the summation and refraction response kinetics were measured. This approach was used to: (1) characterize the behavior of the neural response to central process excitation; (2) make comparisons between intrameatal excitation at a known central site and scala tympani excitation at an unknown site; and (3) provide membrane characterization free from the possible alteration of membrane kinetics produced by the cell soma. The membrane kinetics measured using intrameatal stimulation differ from those recorded with scala tympani stimulation indicating that the mechanisms for scala tympani and intrameatal stimulation differ. (C) 2000 Elsevier Science B.V. All rights reserved.