Co-exposure to phenols and phthalates during pregnancy with the difference of body size in twins at one month old
Co-exposure to phenols and phthalates during pregnancy with the difference of body size in twins at one month old
复制标题
孕期苯酚和邻苯二甲酸盐共同暴露与双胞胎1月龄体型差异
DOI：
10.1016/j.chemosphere.2022.136991
复制
发表时间：
2022
期刊：
影响因子：
8.8
通讯作者：
Yang Pan
中科院分区：
文献类型：
--
作者：
Mei Hong;Deng Langjing;Xie Jinying;Li Xiaojie;Wu Nanxin;Hu Liqin;Huang Guangtong;Mo Fanyu;Chen Da;Xiao Han;Yang Pan
人类同时暴露在苯酚和邻苯二甲酸盐(PAE)中。然而，酚类和PAEs的混合作用对双胞胎的体型影响尚不明显。从2016年到2018年，我们招募了228名怀孕的双胞胎，并采集了多达3份尿样。液-质联用法共检测到8种PAE代谢物和7种酚类物质。对化学单独效应和混合效应进行了评估。多元线性回归结果显示了母亲PAE和苯酚暴露对一个月大双胞胎生长发育差异的百分比变化。在整个三个月期间，这些化学物质与体重差异呈正相关。此外，分位数g计算模型显示，尿中所有化学物质浓度每增加一个四分位数，各孕期双胞胎的体重差异分别为22.85%(95%CI：11.21-35.72%)、22.60%(95%CI：12.31-33.83%)和24.05%(95%CI：13.11-36.05%)。在整个妊娠期间，所有PAE代谢物和酚类增加一个分位数，体重差异增加26.61%(95%CI：15.79%，38.44%)，身高差异增加15.84%(95%CI：3.92%，29.13%)。PAE和苯酚的共同暴露可能在双胞胎的生长发育中起主要作用。
Humans are simultaneously exposed to phenols and phthalates (PAEs). However, the mixture effect of phenols and PAEs on the body size of twins is lacking. From 2016 to 2018, we recruited 228 pregnant twins and collected up to three urine samples. A total of 8 PAE metabolites and 7 phenols were detected in urine by liquid chromatography-tandem mass spectrometry. Chemical individual and mixture effects were estimated. Multivariable linear regression results presented the percentage change in twins' growth differences at one month old with maternal PAE and phenol exposure. These chemicals were positively associated with weight differences during the entire trimester. Moreover, the quantile g-computed model showed that increased urinary concentrations of all chemicals by one quartile were associated with a 22.85% (95%CI: 11.21–35.72%), 22.60% (95%CI: 12.31–33.83%), and 24.05% (95%CI: 13.11–36.05%) larger weight difference within twins in each trimester, respectively. Increasing all PAE metabolites and phenols by one quantile across the entire trimester, weight differences increased by 26.61% (95% CI: 15.79%, 38.44%), and height differences increased by 15.84% (95%CI: 3.92%, 29.13%). Co-exposure to PAEs and phenols may primarily play a role in twins’ growth.