Evolution of the corticosteroid receptor signalling pathway in fish
Evolution of the corticosteroid receptor signalling pathway in fish
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DOI：
10.1016/j.ygcen.2007.03.009
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发表时间：
2007-08-01
影响因子：
2.7
通讯作者：
Sturm, Armin
中科院分区：
文献类型：
--
作者：
Bury, Nicolas R.;Sturm, Armin
皮质类固醇受体 (CR) 控制着大量的生理过程，主要充当配体依赖性转录因子。颌口动物 CR 的起源可以追溯到原始无颌脊椎动物中存在的祖先类固醇受体。据信，早期颌口动物中的基因组复制事件产生了至今仍存在于肉鳍鱼和四足动物中的一组两种 CR，即糖皮质激素 (GR) 和盐皮质激素受体 (MR)，它们具有不同的功能和不同的配体。分别是皮质醇和醛固酮。硬骨鱼的早期进化史中发生了进一步的基因组复制。硬骨鱼 CR 系统似乎已经多样化，现在由 2 个 GR 和一个 MR 组成。硬骨鱼缺乏醛固酮，主要的皮质类固醇被认为是皮质醇。然而，盐皮质激素 11-脱氧皮质酮 (DOC) 已被确定为虹鳟鱼 MR 的激动剂，表明它可能是 MR 的祖先配体。硬骨鱼中两个GR的保留表明其中一个重复基因的新功能化，但这一假设需要进一步的研究。在虹鳟鱼中，两种 GR 的反式激活和反式抑制活性在对糖皮质激素的敏感性方面表现出显着差异，这表明可能允许两种 GR 控制不同生理途径的机制。类似的机制是否存在于整个放线鱼中，或者这是否是鲑科鱼谱系所特有的，仍有待验证。 (c) 2007 Elsevier Inc. 保留所有权利。
The corticosteroid receptors (CR) control a vast array of physiological processes acting primarily as ligand-dependent transcription factors. The origins of the gnathostomata CRs can be traced back to an ancestral steroid receptor present in a primitive agnathan vertebrate. A genome duplication event in the early gnathostomes is believed to have produced a set of two CRs still present today in Sarcopterygii (lobe-finned fish and tetrapods), i.e. a glucocorticoid (GR) and mineralocorticoid receptor (MR), with divergent function and different ligands. cortisol and aldosterone, respectively. A further genome duplication occurred in the early evolutionary history of the teleosts. and the teleost CR system seems to have diversified, consisting now of 2 GRs and a MR. Teleosts lack aldosterone and the main corticosteroid is believed to be cortisol. However, the mineralocorticoid, 11-deoxycorticosterone (DOC), has been identified as an agonist for the rainbow trout MR, suggesting it may be the ancestral ligand for the MR. The retention of two GRs in teleosts suggests neofunctionalisation of one of the duplicated genes, but this hypothesis requires further work. In rainbow trout, transactivation and transrepression activities of the two GRs show marked differences in their sensitivity to glucocorticoids, suggesting a mechanism that may allow the two GRs to control different physiological pathways. Whether a similar mechanism is seen throughout the actinopterygii or whether this is specific to the salmonid lineage remains to be verified. (c) 2007 Elsevier Inc. All rights reserved.