EFFECTS OF VASOACTIVE DRUGS ON CIRCULATION IN CANINE SUBCUTANEOUS ADIPOSE TISSUE
EFFECTS OF VASOACTIVE DRUGS ON CIRCULATION IN CANINE SUBCUTANEOUS ADIPOSE TISSUE
复制标题
DOI：
10.1111/j.1748-1716.1970.tb04759.x
复制
发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
ROSELL, S
中科院分区：
文献类型：
--
作者：
FREDHOLM, BB;OBERG, B;ROSELL, S
在犬皮下脂肪组织中研究了乙酰胆碱、缓激肽、异丙肾上腺素、组胺、5-羟色胺（5-HT）、去甲肾上腺素和前列腺素Ei（PGE 1）的循环效应。PGE 1在计算的低至10 - 9 M的血液浓度下产生明确的血管舒张，并且被发现是测试的药物中最有效的。PGE 1的效力比乙酰胆碱强约1000倍，比组胺强约10倍。5-HT诱导中度血流量增加，组织体积无变化或减少，表明静脉部分收缩。血管对去甲肾上腺素输注的反应基本上类似于交感神经激活所产生的反应，即小动脉和静脉收缩以及毛细血管滤过系数（CFC）显著增加。组胺和缓激肽诱导的CFC增加幅度与交感神经刺激相同，而乙酰胆碱、异丙肾上腺素、5-HT和PGE 1诱导的CFC增加幅度较小。交感神经刺激叠加在输注后的药物产生了进一步显着增加CFC，而神经刺激期间施加的组胺或缓激肽输注产生没有进一步上升，甚至减少CFC。据讨论，在交感神经刺激过程中的显着CFC增加是由于毛细血管膜的渗透性增加。
The circulatory effects of acetylcholine, bradykinin, isoprenaline, histamine, 5‐hydroxytrypt‐amine (5‐HT), noradrenaline and prostaglandin Ei (PGE1) were studied in the canine subcutaneous adipose tissue. PGE1produced clearcut vasodilatations at calculated blood concentrations as low as 10‐9M and was found to be the most potent of the drugs tested. PGE1was about 1000 times more potent than acetylcholine and about 10 times more potent than histamine. 5‐HT induced a moderate blood flow increase with no change or a decrease of tissue volume, indicating a constriction of the venous section. The vascular responses to noradrenaline infusions were essentially similar to those produced by sympathetic nerve activation,i.e. constriction of arterioles and veins and a markedly increased capillary filtration coefficient (CFC). Histamine and bradykinin induced increases of CFC of the same magnitude as did sympathetic nerve stimulation, whereas acetylcholine, isoprenaline, 5‐HT and PGE1induced smaller increases of CFC. Sympathetic nerve stimulation superimposed upon infusions of the latter drugs produced a further marked increase of CFC, while nerve stimulation applied during a period of histamine or bradykinin infusion produced no further rise or even a decrease of CFC. It is discussed that the pronounced CFC increase during sympathetic nerve stimulation is due to an increased permeability of the capillary membrane.