Ventral medullary surface inputs to cervical sympathetic respiratory oscillations.
Ventral medullary surface inputs to cervical sympathetic respiratory oscillations.
复制标题
腹侧延髓表面输入颈交感呼吸振荡。
DOI：
10.1152/ajpregu.1987.252.6.r1032
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Cherniack,NS
中科院分区：
文献类型：
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作者：
VanLunteren,E;Mitra,J;Prabhakar,NR;Haxhiu,MA;Cherniack,NS
为了研究局部冷却腹侧延髓表面（VMS）的三个区域（喙，中间和尾部）对颈交感神经和膈神经活动中呼吸振荡的影响，12只猫被麻醉，迷走神经切断，麻痹，并人工通气与7%CO2的O2。将中间区域从37 ℃冷却至20 ℃显著降低了颈交感神经活动（P <0.001）和膈神经活动（P <0.001）的呼吸振荡幅度。所有三个区域的分级冷却导致交感神经相关活动的分级减少，这与膈神经活动的减少相当。交感神经呼吸振荡的减少幅度是最大的中间区域，其次是尾侧和喙侧区域。8只猫还接受了分级VMS冷却，同时用含3% CO2的O2和100% O2通气。在每个水平的吸入CO2，分级冷却导致交感神经活动的呼吸振荡的分级减少;相反，在每个髓温，吸入CO2的分级增加导致颈部交感神经呼吸活动的分级增加。这些结果表明，所有三个领域的VMS影响呼吸振荡的颈交感神经活动，虽然在不同程度上。
To examine the effects of focally cooling three areas (rostral, intermediate, and caudal) of the ventral medullary surface (VMS) on respiratory oscillations in cervical sympathetic and phrenic nerve activity, 12 cats were anesthetized, vagotomized, paralyzed, and artificially ventilated with 7% CO2 in O2. Cooling the intermediate area from 37 to 20 degrees C significantly reduced the magnitude of respiratory oscillations in both cervical sympathetic activity (P less than 0.001) and phrenic activity (P less than 0.001). Graded cooling of all three areas caused graded reductions in sympathetic respiratory-related activity that were comparable to the reductions in phrenic activity. The magnitude of the reductions in sympathetic respiratory oscillations was greatest for the intermediate area, followed in order by the caudal and rostral areas. Eight cats also underwent graded VMS cooling while ventilated with 3% CO2 in O2 and 100% O2. At each level of inspired CO2, graded cooling resulted in graded reductions in respiratory oscillations in sympathetic activity; conversely, at each medullary temperature, graded increases in inspired CO2 caused graded increases in cervical sympathetic respiratory activity. These results suggest that all three areas of the VMS influence respiratory oscillations in cervical sympathetic activity, although to different extents.