Inter-rater reliability of a classification system for hospital adverse drug event reports.
Inter-rater reliability of a classification system for hospital adverse drug event reports.
复制标题
医院药品不良事件报告分类系统的评估者间可靠性。
DOI：
10.1038/sj.clpt.6100322
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发表时间：
2008
影响因子：
6.7
通讯作者：
Linkin,DR
中科院分区：
文献类型：
--
作者：
Haynes,K;Hennessy,S;Morales,KH;Gibson,GA;Barnhart,C;Jaipaul,CK;Linkin,DR
医院药物警戒系统经常根据严重程度和结局类型等不同轴对药物不良事件（ADE）报告进行分类，以更好地检测某些类型ADE的频率变化。本研究旨在测量ADE分类系统的观察者间可靠性。两名药剂师和两名内科医生审查了150份药剂师生成的ADE报告，并使用结构化表格对四个领域的报告进行分类：存在或不存在导致ADE的过程措施;启动可能导致ADE的过程的个人; ADE的严重程度;以及ADE是否与剂量相关。ADE分类系统中不同元素的观察者间可靠性存在很大差异。与ADE相关的特定过程的一致性从差到中等不等，这限制了准确靶向过程以提高药物利用率的能力。临床药理学与治疗学（2008）83，3，485-488.doi：10.1038/sj.clpt.6100322
Hospital pharmacovigilance systems frequently classify adverse drug event (ADE) reports on various axes such as severity and type of outcome in an attempt to better detect changes in the frequency of certain types of ADEs. The aim of this study was to measure the inter‐observer reliability of an ADE classification system. Two pharmacists and two internal medicine physicians reviewed 150 pharmacist‐generated ADE reports and used a structured form to classify reports on four domains: the presence or absence of process measures leading to ADE; the individual who initiated the process that potentially leads to ADE; the severity of ADE; and whether the ADE was related to dose. There was wide variation in inter‐observer reliability of different elements in a classification system for ADEs. Agreement on specific processes associated with ADEs ranged from poor to moderate, which limits the ability to target accurately processes to improve drug utilization.Clinical Pharmacology & Therapeutics(2008)83, 3, 485–488.doi:10.1038/sj.clpt.6100322