Ipsilateral turning behavior induced by unilateral microinjections of a cannabinoid into the rat subthalamic nucleus.
Ipsilateral turning behavior induced by unilateral microinjections of a cannabinoid into the rat subthalamic nucleus.
复制标题
将大麻素单侧微注射到大鼠丘脑底核中诱导同侧转向行为。
DOI：
10.1016/s0006-8993(97)01475-3
复制
发表时间：
1998
期刊：
影响因子：
2.9
通讯作者：
Walker,JM
中科院分区：
文献类型：
--
作者：
Miller,AS;Sañudo-Peña,MC;Walker,JM
丘脑下核含有大麻素受体和大麻素受体mRNA。然而，大麻素受体在该细胞核中的作用尚未得到研究。为了研究大麻素受体在大鼠丘脑底核中的功能作用，我们观察了单侧显微注射合成大麻素CP 55,940后大鼠丘脑底核的转向活性。CP 55,940 （10 μg）诱导同侧侧翻。大麻素受体拮抗剂SR141716A （5 μg）可阻断这种作用。这些结果表明，大麻素受体在丘脑下核介导运动活动的抑制。
The subthalamic nucleus contains cannabinoid receptors and cannabinoid receptor mRNA. However, the role of cannabinoid receptors in this nucleus has not been examined. In order to investigate the functional role of cannabinoid receptors in the rat subthalamic nucleus, turning activity was observed following unilateral microinjection of the synthetic cannabinoid CP 55,940. CP 55,940 (10 μg) induced ipsilateral turning. This effect was blocked by coadministration of the cannabinoid receptor antagonist SR141716A (5 μg). These results suggest that cannabinoid receptors in the subthalamic nucleus mediate an inhibition of motor activity.