TREATMENT OF PERSISTENT EPITHELIAL DEFECTS IN NEUROTROPHIC KERATITIS WITH EPIDERMAL GROWTH-FACTOR - A PRELIMINARY OPEN STUDY
TREATMENT OF PERSISTENT EPITHELIAL DEFECTS IN NEUROTROPHIC KERATITIS WITH EPIDERMAL GROWTH-FACTOR - A PRELIMINARY OPEN STUDY
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DOI：
10.1007/bf00165937
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发表时间：
1992-07-01
影响因子：
2.7
通讯作者：
SCHEPENS, CL
中科院分区：
文献类型：
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作者：
DANIELE, S;GILBARD, JP;SCHEPENS, CL
我们报告了三例持续性上皮缺损的神经营养性角膜病变的患者，这些患者在局部应用小鼠源性表皮生长因子（m-EGF）治疗时愈合。这些患者的临床过程是惊人的，并表明，表皮生长因子可能有一个潜在的作用，在治疗持续上皮缺损的受试者患有神经营养性角膜炎。
We report three patients with persistent epithelial defects in the context of neurotrophic keratopathy that healed while on treatment with topically applied, mouse-derived epidermal growth factor (m-EGF). The clinical course of these patients was striking and suggests that EGF may have a potential role in the treatment of persistent epithelial defects in subjects suffering from neurotrophic keratitis.