Human radiation dosimetry of 6-[18F]FDG predicted from preclinical studies.
Human radiation dosimetry of 6-[18F]FDG predicted from preclinical studies.
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根据临床前研究预测的 6-[18F]FDG 人体辐射剂量测定。
DOI：
10.1118/1.4866217
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发表时间：
2014
期刊：
影响因子：
3.8
通讯作者：
Ismail-Beigi,Faramarz
中科院分区：
文献类型：
--
作者：
MuzicJr,RaymondF;Chandramouli,Visvanathan;Huang,Hsuan-Ming;Wu,Chunying;Hatami,Ahmad;Ismail-Beigi,Faramarz
目的作者正在开发 6-[{sup 18}F]氟-6-脱氧-D-葡萄糖 (6-[{sup 18}F]FDG) 作为葡萄糖转运的体内示踪剂。虽然 6-[{sup 18}F]FDG 与广泛用于 PET 成像的 2-[{sup 18}F]氟-2-脱氧-D-葡萄糖 (2-[{sup 18}F]FDG) 具有相同的放射性核素半衰期，但 6-[{sup 18}F]FDG 具有特殊的生物学特性和不同的生物分布，使其更适合用于 2-[{sup 18}F]FDG 用于评估葡萄糖转运。为了准备将 6-[{sup 18}F]FDG 用于人体 PET 扫描，作者希望确定注射的 6-[{sup 18}F]FDG 量，同时将辐射剂量保持在安全范围内。方法给大鼠注射 6-[{sup 18}F]FDG，在指定时间实施安乐死，收集组织并测定活性含量。对于每个组织样本，计算每克注射剂量的百分比并外推至人类，以构建预测的时间进程。停留时间计算为曲线下面积，并用作 OLINDA/EXM 的输入，以计算辐射剂量。结果与 2-[{sup 18}F]FDG 不同，膀胱壁因尿液排泄而接收最高吸收剂量，而 6-[{sup 18}F]FDG 则几乎没有尿液排泄和成骨细胞 预计肝脏将接收最高吸收剂量：分别为 0.027 mGy/MBq (0.100 rad/mCi) 和 0.018 mGy/MBq (0.066 rad/mCi)。此外，6-[{sup 18}F]FDG 的有效剂量，即 0.013 mSv/MBq (0.046 rem/mCi)，预计比 2-[{sup 18}F]FDG 的有效剂量低约 30%。结论 6-[{sup 18}F]FDG 可安全用于人体 PET 扫描。
PurposeThe authors are developing 6-[{sup 18}F]fluoro-6-deoxy-D-glucose (6-[{sup 18}F]FDG) as an in vivo tracer of glucose transport. While 6-[{sup 18}F]FDG has the same radionuclide half-life as 2-[{sup 18}F]fluoro-2-deoxy-D-glucose (2-[{sup 18}F]FDG) which is ubiquitously used for PET imaging, 6-[{sup 18}F]FDG has special biologic properties and different biodistributions that make it preferable to 2-[{sup 18}F]FDG for assessing glucose transport. In preparation for 6-[{sup 18}F]FDG use in human PET scanning, the authors would like to determine the amount of 6-[{sup 18}F]FDG to inject while maintaining radiation doses in a safe range.MethodsRats were injected with 6-[{sup 18}F]FDG, euthanized at specified times, and tissues were collected and assayed for activity content. For each tissue sample, the percent of injected dose per gram was calculated and extrapolated to that for humans in order to construct predicted time-courses. Residence times were calculated as areas under the curves and were used as inputs to OLINDA/EXM in order to calculate the radiation doses.ResultsUnlike with 2-[{sup 18}F]FDG for which the urinary bladder wall receives the highest absorbed dose due to urinary excretion, with 6-[{sup 18}F]FDG there is little urinary excretion and osteogenic cells and the liver are predicted to receive the highest absorbed doses: 0.027 mGy/MBq (0.100 rad/mCi) and 0.018 mGy/MBq (0.066 rad/mCi), respectively. Also, the effective dose from 6-[{sup 18}F]FDG, i.e., 0.013 mSv/MBq (0.046 rem/mCi), is predicted to be approximately 30% lower than that from 2-[{sup 18}F]FDG.Conclusions6-[{sup 18}F]FDG will be safe for use in the PET scanning of humans.