Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment
Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment
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DOI：
10.1016/j.coph.2014.08.006
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发表时间：
2014-12-01
影响因子：
4
通讯作者：
Kortenkamp, Andreas
中科院分区：
文献类型：
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作者：
Kortenkamp, Andreas
今天的化学品暴露的特点是广泛传播的污染毯，由无数的化学品组成，其中许多是内分泌干扰物，所有这些都是相当低的水平。由于其重点是逐一考虑单一化学品，世界各地的监管机构用于化学品安全评估的方法无法跟上这些污染模式。一项重大挑战是评估大量低剂量内分泌干扰物和其他化学品的综合影响。我们追溯评估低剂量混合物所需的实验和概念方法的发展，重点是与内分泌干扰化学品的工作。我们发现，近20年的研究已经产生了很好的证据，在实验阈值附近的水平的组合效应。在决定这一证据的相关性时遇到的一个障碍是，关于构成综合接触的干扰内分泌的化学品范围的信息不完整。正如目前在“棘手的研究”标题下所讨论的那样，这些知识差距迫切需要填补。
Today's chemical exposures are characterised by a widely spread blanket of contamination composed of myriads of chemicals, many of them endocrine disrupters, all at rather low levels. With their focus on considering single chemicals one by one, the approaches used by regulatory bodies worldwide for safety assessments of chemicals cannot keep up with these pollution patterns. A substantial challenge lies in the assessment of combination effects from large numbers of endocrine disrupters and other chemicals, all at low doses. We retrace the development of experimental and conceptual approaches required for assessing low dose mixtures, with an emphasis on work with endocrine disrupting chemicals. We find that nearly 20 years of research has produced good evidence for combination effects at levels around experimental thresholds. One obstacle in deciding on the relevance of this evidence is incomplete information about the range of endocrine-disrupting chemicals that make up combined exposures. These knowledge gaps need to be closed urgently, as is currently discussed under the heading of exposome research.