Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration.
Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration.
复制标题
DOI：
10.1093/ajcn/85.3.762
复制
发表时间：
2007-03
期刊：
影响因子：
--
通讯作者：
Wei Wang;S. Connor;Elizabeth J Johnson;M. Klein;S. Hughes;W. Connor
中科院分区：
文献类型：
--
作者：
Wei Wang;S. Connor;Elizabeth J Johnson;M. Klein;S. Hughes;W. Connor
背景：低饮食摄入量和低血浆叶黄素和玉米黄质浓度与老年性黄斑变性(AMD)的风险增加相关。没有研究挑战高叶黄素和玉米黄质饮食的AMD患者。目的探讨低、高叶黄素和玉米黄质饮食对AMD患者血浆类胡萝卜素及其转运的影响。设计：7名AMD患者和5名对照受试者分别以低叶黄素、低玉米黄质饮食(约1.1 mg/d)喂养2wk，随后给予高叶黄素、高玉米黄质饮食(约11 mg/d)4wk。10名受试者继续饮食8wk。用高效液相色谱法测定血浆和脂蛋白类胡萝卜素含量。结果高叶黄素、高玉米黄质饮食使AMD患者和对照组血浆中叶黄素、玉米黄质和除番茄红素外的其他类胡萝卜素浓度增加2~3倍。在这种饮食中，52%的叶黄素和44%的玉米黄质是由高密度脂蛋白运输的；大约22%的叶黄素和玉米黄质是由低密度脂蛋白运输的。只有20%-25%的α-胡萝卜素、β-胡萝卜素和番茄红素由高密度脂蛋白运输；50%-57%由低密度脂蛋白运输。结论AMD患者和对照组对高叶黄素和玉米黄质饮食的反应相似，两组血浆类胡萝卜素浓度均显著升高，脂蛋白转运类胡萝卜素的作用无显著差异。这一发现表明，AMD中叶黄素和玉米黄质代谢的异常可能存在于从血浆中摄取叶黄素和玉米黄质并转运到视网膜中。
BACKGROUND Low dietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin. OBJECTIVE The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients. DESIGN Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet ( approximately 1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet ( approximately 11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC. RESULTS The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52% of the lutein and 44% of the zeaxanthin were transported by HDL; approximately 22% of lutein and zeaxanthin was transported by LDL. Only 20-25% of alpha-carotene, beta-carotene, and lycopene was transported by HDL; 50-57% was transported by LDL. CONCLUSIONS The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina.