Molecular mechanisms of vascular permeability in diabetic retinopathy.
Molecular mechanisms of vascular permeability in diabetic retinopathy.
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DOI：
10.3109/08820539909069543
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发表时间：
1999-12-01
影响因子：
1.7
通讯作者：
Gardner, T W
中科院分区：
文献类型：
--
作者：
Antonetti, D A;Lieth, E;Gardner, T W
糖尿病在人类中导致广泛的并发症，包括肾衰竭、血管疾病、周围神经变性和视力丧失。糖尿病视网膜病变导致失明的工作年龄的人在美国比任何其他疾病，并大大有助于失明的年轻人和老年人以及。我们社会中糖尿病发病率的增加只会导致这个国家的视觉健康进一步下降，除非发现新的方法来预防和治疗糖尿病视网膜病变。血-视网膜屏障的破坏和由此产生的血管渗透性仍然是糖尿病视网膜病变中最先观察到的改变之一，并且与视力丧失密切相关。在本文中，我们研究了形成这种血视网膜屏障的分子成分，并探索神经实质中生长因子产生的变化如何导致血管渗透性增加并导致视网膜变性。
Diabetes leads to a wide array of complications in humans, including kidney failure, vascular disease, peripheral nerve degeneration, and vision loss. Diabetic retinopathy causes blindness in more working-age people in the United States than any other disease and contributes greatly to blindness in the young and old as well. The increasing rate of diabetes occurring in our society can only bring about a further decrease in the visual health of this country unless new modalities are discovered to prevent and cure diabetic retinopathy. Breakdown of the blood-retinal barrier and the resultant vascular permeability remains one of the first observable alterations in diabetic retinopathy and strongly correlates with vision loss. In this article, we examine the molecular components that form this blood-retinal barrier and explore how changes in the production of growth factors in the neural parenchyma cause an increase in vascular permeability and contribute to retinal degeneration.