Immunoregulation by sympathetic nervous system
Immunoregulation by sympathetic nervous system
复制标题
交感神经系统的免疫调节
DOI：
10.1016/0165-6147(81)90324-2
复制
发表时间：
1981
影响因子：
13.8
通讯作者：
E. Sorkin
中科院分区：
文献类型：
--
作者：
H. Besedovsky;M. Prada;A. Rey;E. Sorkin
在哺乳动物中，免疫系统由多种调节机制组成，包括参与免疫反应的B淋巴细胞和T淋巴细胞。每个约10‘g细胞，以及巨噬细胞等辅助细胞。虽然B淋巴细胞主要用于产生抗体，但T淋巴细胞的不同亚群具有辅助、抑制或杀伤功能，这两类细胞被细分为具有不同特异性的克隆体。这两种类型的细胞都表达大量的细胞表面受体，可以识别数百万种抗原。免疫系统就像一台复杂的识别机器，由基因决定的相互作用细胞网络组成，交换各种特定和非特定的信号。随着人们对免疫系统中细胞和体液成分的认识不断加深，目前主要致力于阐明抗原挑战，至少提出了四种控制免疫系统的自身调节机制：(1)辅助和抑制T细胞及其产物，(2)抗体反馈系统(S)，(3)相互作用的抗体的独特型-抗独特型网络，(4)指定调节因子FIr反应的基因。到目前为止，获得的实验结果表明，免疫系统可以拥有与身体其他系统类似的一定程度的自主性。因此，免疫系统可以在其生理和解剖环境之外的体外运行也就不足为奇了。然而，激素和神经递质通常存在于免疫细胞的环境中，并影响其性能。此外，免疫系统之间的动态相互作用
In mammals, the immune system consists of the multiple regulatory mechanisms of B-and T lymphocytes comprising in involved in the immune response. Followman about 10'g cells each, and accessory cells such as macrophages. While B-lymphocytes are mainly committed to produce antibodies, different subsets of T lympht) cyles possess, am~ mg others, helper, suppressor or killer functions, These two populations of cells are subdivided into clones with differing specificities. Both cell types express a huge repertoire of cellsurface receptors which allows recognition of several millions of antigens. The immune system behaves as a complex recognition machine, organized in a genetically determined network of interacting cells which exchange a variety of specific and non-specific signals. As a consequence of the increasing knowledge of the cellular and humoral elements of the immune system, major efforts are directed now to the elucidation ing antigenic challenge, at least four autoregulatory mechanisms have been proposed for the control of the immune system:(1) helper and suppressor T cells and their products,(2) antibody feedback system (s),(3) idiotypic-anti-idiotypic network of interacting antibodies,(4) genes specifying regulatory factors fi) r response. To date, the experimental findings obtained indicate that the immune system could have a degree of autonomy similar to that of other systems of the body. It is therefore not surprising that the immtlne system can operate hi vitro outside its physiological and anatomical environment. Hormones and neurotransmitters, however, are normally present in the environment of immunological cells and influence their performance. Moreover, dynamic interactions between the immune~, ystem