Palladium-103 plaque radiotherapy for choroidal melanoma: An 11-year study
Palladium-103 plaque radiotherapy for choroidal melanoma: An 11-year study
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DOI：
10.1016/s0360-3016(02)03751-3
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发表时间：
2002-12-01
影响因子：
7
通讯作者：
Szechter, A
中科院分区：
文献类型：
--
作者：
Finger, PT;Berson, A;Szechter, A
目的：描述11年的经验与Pd-103眼斑近距离放射治疗眼内melanoma.Methods和Materials：自1990年以来，152例患者已被诊断为葡萄膜黑色素瘤，发现是阴性的转移性疾病，并与Pd-103放射性斑放疗治疗。本研究介绍了前100例接受Pd-103治疗并随访≥ 2年的患者。将斑块缝合到巩膜外层以覆盖眼内肿瘤的基部。治疗涉及在5-7天的连续治疗期间输送平均根尖放射剂量80.5戈伊。患者进行了评估，局部肿瘤控制，视力，辐射损伤（视网膜病变，视神经病变，白内障），和转移diseases.Results：在这一系列的患者进行了随访，平均为4.6年（55.4个月）。发现Pd-103种子在斑块制造和剂量测定计算的容易性方面与I-125等同。我们注意到96%的局部控制率和6例继发性眼球摘除。包括摘除的患者，视力评价显示，35%失去了6个或更多的视力线和73%的视力为20/200或更好的结论：长期的结果，现在存在描述使用Pd-103斑块放射治疗葡萄膜（虹膜，睫状体和脉络膜）黑色素瘤。与使用I-125的中心的结果相比，该系列中的患者具有相同的局部控制率和更好的视觉功能。(C)2002年爱思唯尔科学公司
Purpose: To describe 11 years of experience with Pd-103 ophthalmic plaque brachytherapy for intraocular melanoma.Methods and Materials: Since 1990, 152 patients have been diagnosed with uveal melanoma, found to be negative for metastatic disease, and treated with Pd-103 radioactive plaque radiotherapy. This study presents the first 100 patients treated with Pd-103 and followed for greater than or equal to2 years. Plaques were sewn to the episclera to cover the base of the intraocular tumor. Treatment involved delivery of a mean apical radiation dose of 80.5 Gy during 5-7 days continuous treatment. Patients were evaluated for local tumor control, visual acuity, radiation damage (retinopathy, optic neuropathy, cataract), and metastatic disease.Results: Patients in this series were followed for a mean of 4.6 years (55.4 months). Pd-103 seeds were found to be equivalent to I-125 with respect to plaque manufacture and ease of dosimetric calculations. We noted a local control rate of 96% and six secondary enucleations. Including the enucleated patients, the visual acuity evaluations revealed that 35% lost six or more lines of vision and 73% had vision of 20/200 or better.Conclusion: Long-term results now exist describing the use of Pd-103 plaque radiotherapy for uveal (iris, ciliary body, and choroidal) melanoma. Compared with the results from centers using I-125, patients in this series experienced equivalent local control rates and better visual function. (C) 2002 Elsevier Science Inc.