Progesterone and 3 alpha-androstanediol conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA.
Progesterone and 3 alpha-androstanediol conjugated to bovine serum albumin affects estrous behavior when applied to the MBH and POA.
复制标题
当应用于 MBH 和 POA 时，与牛血清白蛋白缀合的黄体酮和 3 α-雄烷二醇会影响动情行为。
DOI：
10.1037//0735-7044.110.3.603
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发表时间：
1996
影响因子：
1.9
通讯作者：
Erskine,MS
中科院分区：
文献类型：
--
作者：
Frye,CA;VanKeuren,KR;Rao,PN;Erskine,MS
切除卵巢的大鼠在内侧基底下丘脑 (MBH) 上插管，植入牛血清白蛋白缀合的 3α-二醇 (BSA; 3α-二醇: BSA)、用 BSA 稀释的游离 3α-二醇 (3α-二醇&BSA)、与 BSA 缀合的孕酮 (PRE) (PRE: BSA)、用 BSA 稀释的游离 PRE (PRE&BSA)，或单独 BSA。 3α-二醇：BSA 或 3α-二醇&BSA 在 90 分钟内促进接受。其他接受雌二醇治疗的大鼠在视前区（POA）接受类固醇植入；接受 PRE: BSA 或 PRE&BSA 的患者在 5 分钟内表现出脊柱前凸显着升高。当给予全身 PRE 时，3α-二醇：BSA 和 3α-二醇＆BSA 应用于 MBH 或 POA 抑制接受性。当全身给予 3α-二醇时，3α-二醇：BSA 植入 MBH 和 POA 产生促进作用。这些数据表明 3α-二醇可以作用于膜，并且这些作用受到循环类固醇的影响；然而，膜介导的行为并不能解释 MBH 和 POA 中所有 PRE 促进的性行为。（PsycInfo 数据库记录 (c) 2024 APA，保留所有权利）
Ovariectomized rats with cannula over the medial basal hypothalamus (MBH) received implants of 3α-diol conjugated to bovine serum albumin (BSA; 3α-diol: BSA), free 3α-diol diluted with BSA (3α-diol&BSA), progesterone (PRE) conjugated to BSA (PRE: BSA), free PRE diluted with BSA (PRE&BSA), or BSA alone. 3α-diol: BSA or 3α-diol&BSA facilitated receptivity within 90 min. Other estradiol-treated rats received steroid implants in the preoptic area (POA); those receiving PRE: BSA or PRE&BSA showed significant elevations in lordosis in 5 min. When systemic PRE was given, 3α-diol: BSA and 3α-diol&BSA applied to the MBH or POA inhibited receptivity. When 3α-diol was given systemically, 3α-diol: BSA implants to the MBH and POA produced facilitatory effects. These data suggest 3α-diol can act at the membrane and that these effects are influenced by circulating steroids; yet membrane-mediated actions do not account for all of PRE-facilitated sexual behavior in the MBH and POA.(PsycInfo Database Record (c) 2024 APA, all rights reserved)