A new genetic distance with application to constrained variation at microsatellite loci.

A new genetic distance with application to constrained variation at microsatellite loci.
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一种新的遗传距离,应用于微卫星位点的受限变异。

DOI:
10.1093/oxfordjournals.molbev.a026128
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发表时间:
1999
影响因子:
10.7
通讯作者:
Zhivotovsky,LA
Zhivotovsky,LA
中科院分区:
生物学1区
文献类型:
--
作者:
Zhivotovsky,LA

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微卫星位点的遗传变异应该被限制在等位基因大小的某个范围内。在这种情况下,两个分歧群体之间的平均平方距离 (delta mu)2 渐近移动,并低估了群体分裂以来的时间。引入了基于平均重复分数 DR 中基因座间相关性的距离。数值模拟表明,如果约束由线性向心力近似,则 DR 是时间的线性函数,这可能是由于对一定范围的突变偏差,或者是由对较大等位基因大小的定向突变偏差和针对较大重复次数的选择引起的。
Genetic variation at microsatellite loci is supposed to be constrained within some range in allele size. In this case, the average-square distance (delta mu)2 between two diverged populations moves asymptotically around and underestimates the time since the populations had split. A distance based on the between-locus correlation in the mean repeat scores, DR, is introduced. Numerical simulations show that DR is a linear function of time if the constraints are approximated by a linear centripetal force, which might be due to mutation bias toward a definite range or be caused both by directional mutation bias toward larger allele size and by selection against the greater number of repeats.
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