Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours.
Multiple deleted regions on the long arm of chromosome 6 in astrocytic tumours.
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DOI：
10.1054/bjoc.1999.0961
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发表时间：
2000-02
影响因子：
8.8
通讯作者：
Collins VP
中科院分区：
文献类型：
--
作者：
Miyakawa A;Ichimura K;Schmidt EE;Varmeh-Ziaie S;Collins VP
6号染色体缺失在包括神经胶质瘤在内的人类肿瘤中很常见。为了研究6号染色体在星形细胞瘤中常见缺失区域的频率，我们利用31个染色体微卫星标记分析了159例肿瘤（106例胶质母细胞瘤、39例间变性星形细胞瘤和14例恶性II级星形细胞瘤）。95%的等位基因丢失病例的损失影响6q。等位基因缺失在星形细胞瘤II级恶性肿瘤中并不常见（14%），但在间变性星形细胞瘤（38%）和胶质母细胞瘤（37%）中更为常见。在星形细胞瘤和间变性星形细胞瘤中经常观察到克隆异质性的证据（即有和没有6号染色体缺失的亚群共存）。克隆异质性在胶质母细胞瘤中较少见。在6q上发现了5个常被删除的区域。这些观察结果表明，一些肿瘤抑制基因位于6q上，这些基因可能参与星形细胞肿瘤的进展。©2000癌症研究运动
Chromosome 6 deletions are common in human neoplasms including gliomas. In order to study the frequency and identify commonly deleted regions of chromosome 6 in astrocytomas, 159 tumours (106 glioblastomas, 39 anaplastic astrocytomas and 14 astrocytomas malignancy grade II) were analysed using 31 microsatellite markers that span the chromosome. Ninety-five per cent of cases with allelic losses had losses affecting 6q. Allelic losses were infrequent in astrocytomas malignancy grade II (14%) but more usual in anaplastic astrocytomas (38%) and glioblastomas (37%). Evidence for clonal heterogeneity in the astrocytomas and anaplastic astrocytomas was frequently observed (i.e. co-existence of subpopulations with and without chromosome 6 deletions). Clonal heterogeneity was less common in glioblastomas. Five commonly deleted regions were identified on 6q. These observations suggest that a number of tumour suppressor genes are located on 6q and that these genes may be involved in the progression of astrocytic tumours. © 2000 Cancer Research Campaign