Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors
Stereoselective total synthesis of serine palmitoyl-CoA transferase inhibitors
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丝氨酸棕榈酰辅酶A转移酶抑制剂的立体选择性全合成
DOI：
10.1055/s-2006-942475
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发表时间：
2006
期刊：
影响因子：
--
通讯作者：
R. Bittman
中科院分区：
文献类型：
--
作者：
H. Byun;Xuequan Lu;R. Bittman
本综述总结了真菌代谢物 mycestericin、myriocin、viridiofungin、sulfamisterin 和 sphingofungin 的全合成。合成分为三个部分：(a) 长链和 (b) 极性头基的制备，以及 (c) 分子两部分的偶联。还简要描述了这些丝氨酸棕榈酰辅酶 A 转移酶（鞘脂生物合成中的限速酶）的有效抑制剂的作用机制。
This review summarizes the total syntheses of the fungal metabolites mycestericin, myriocin, viridiofungin, sulfamisterin, and sphingofungin. The syntheses are organized into three sections: the preparation of (a) the long chain and (b) the polar head group, and (c) the coupling of the two parts of the molecule. The mechanism of action of these potent inhibitors of serine palmitoyl-CoA transferase, the rate-limiting enzyme in the biosynthesis of sphin-golipids, is also briefly described.